Dynamic rRNA modifications as a source of ribosome heterogeneity.

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-11-04 DOI:10.1016/j.tcb.2024.10.001
Ivan Milenkovic, Eva Maria Novoa
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引用次数: 0

Abstract

Ribosomal RNAs (rRNA) are the most abundant RNA molecules in almost all cell types. The general consensus in the field is that rRNA modifications are largely species-specific, with most previous works and databases solely stratifying modifications by the species of origin, without taking other levels of complexity into account. However, new evidence has emerged suggesting dynamic rRNA modifications may have additional layers of complexity and might play an important role in development and disease. In this review article, we summarize recent evidence supporting heterogeneity and dynamics in rRNA modifications in diverse biological contexts, challenging the simplistic view of 'one-species-one-rRNA-modification-pattern'. Moreover, we highlight how rRNA modification dynamics have been studied to date and how long-read sequencing methods can significantly improve our understanding of this largely unexplored yet highly abundant RNA family, across tissues, developmental stages, and diseases.

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动态 rRNA 修饰是核糖体异质性的来源。
核糖体 RNA(rRNA)是几乎所有细胞类型中最丰富的 RNA 分子。该领域的普遍共识是,rRNA 的修饰在很大程度上是物种特异性的,以前的大多数研究工作和数据库都只是根据起源物种对修饰进行分层,而没有考虑其他层次的复杂性。然而,新的证据表明,动态 rRNA 修饰可能具有更多层次的复杂性,并可能在发育和疾病中发挥重要作用。在这篇综述文章中,我们总结了支持 rRNA 修饰在不同生物环境中的异质性和动态性的最新证据,对 "一种物种一种 rRNA 修饰模式 "的简单化观点提出了质疑。此外,我们还强调了迄今为止对 rRNA 修饰动态的研究情况,以及长读程测序方法如何能显著提高我们对这一在组织、发育阶段和疾病中基本未被探索但却非常丰富的 RNA 家族的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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