{"title":"Kokum Butter and Sesame Oil-Based Oleogels as Novel Nutraceutical Delivery Systems","authors":"Dheerendra Kumar Suman, Kunal Pal, Biswaranjan Mohanty* and Rajeswara Reddy Erva*, ","doi":"10.1021/acs.cgd.4c0120510.1021/acs.cgd.4c01205","DOIUrl":null,"url":null,"abstract":"<p >Novel oleogel formulations for nutraceutical administration using sesame oil (SO) and kokum butter (KB) were presented. KB aligned and enhanced formulation by entrapping the SO. SO–KB gelation required 20% w/w. KB (22.5–35% w/w) was utilized to make oleogel formulations. Oleogels, according to various microscopes, showed fat molecules aggregating in the oil matrix. Fourier transform infrared (FTIR) spectroscopy showed no molecular interactions between the oil and butter molecules. Mechanical studies showed that oleogel formulations are viscoelastic and strengthen with increasing KB. The formulation with more KB exhibited the highest crystallization rate and nucleation process. X-ray diffraction (XRD) evaluation showed that the formulation with the highest KB concentration had the largest crystalline particle size. A drug release study explored how KB affected curcumin (CRU) release at pH 6.8 and 1.2. Finally, these oleogels showed promising nutraceutical delivery functions.</p>","PeriodicalId":3,"journal":{"name":"ACS Applied Electronic Materials","volume":null,"pages":null},"PeriodicalIF":4.3000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Electronic Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.cgd.4c01205","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
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Abstract
Novel oleogel formulations for nutraceutical administration using sesame oil (SO) and kokum butter (KB) were presented. KB aligned and enhanced formulation by entrapping the SO. SO–KB gelation required 20% w/w. KB (22.5–35% w/w) was utilized to make oleogel formulations. Oleogels, according to various microscopes, showed fat molecules aggregating in the oil matrix. Fourier transform infrared (FTIR) spectroscopy showed no molecular interactions between the oil and butter molecules. Mechanical studies showed that oleogel formulations are viscoelastic and strengthen with increasing KB. The formulation with more KB exhibited the highest crystallization rate and nucleation process. X-ray diffraction (XRD) evaluation showed that the formulation with the highest KB concentration had the largest crystalline particle size. A drug release study explored how KB affected curcumin (CRU) release at pH 6.8 and 1.2. Finally, these oleogels showed promising nutraceutical delivery functions.
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