Computational insights into tumor invasion dynamics: A finite element approach

Abstract

The finite element scheme is proposed and analyzed for the solution of an acid-mediated tumor invasion model. The reaction–diffusion equation shows the evolution in the tumor cell density, $H^{+}$ ions concentration, and healthy tissue density over time. The coupled non-linear partial differential equations are discretized in time with the implicit Euler method and in space with standard Galerkin finite element. To solve the non-linear and coupled terms of the system a fixed point iteration scheme is presented. Moreover, a mass-lumped scheme is adopted to reduce the computation cost. The cut-off method is used to compute the bounded solutions of the PDEs. Finally, The effects of proliferation rate and healthy tissue degradation rate are investigated.