Structural optimization and in vitro corrosion analysis of biodegradable Mg-Nd-Zn-Zr alloy clip

IF 3.3 2区 医学 Q2 ENGINEERING, BIOMEDICAL Journal of the Mechanical Behavior of Biomedical Materials Pub Date : 2024-10-31 DOI:10.1016/j.jmbbm.2024.106790
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Abstract

Magnesium (Mg) alloy which benefits from biodegradability and mechanical characteristics offers great potential for the development of degradable hemostatic clips. However, the deformation process induces stress concentration, which in turn accelerates the corrosion rate of Mg hemostatic clips. In this study, two types of R-shape clips based on Mg-Nd-Zn-Zr alloy were designed with structural features of no teeth and staggered teeth and simulated using finite element analysis (FEA), and the corrosion behaviors of the Mg clips were investigated by immersion test and electrochemical measurement. Furthermore, the clamping properties of the Mg clips were evaluated by burst pressure test. The simulation results showed that the R-shape clip with staggered teeth caused the minimum stress (1.237 MPa) to blood vessels. After the clamping deformation process, the closed clips remained intact without any signs of cracking. In vitro degradation analysis indicated that the corrosion rate of the closed clip was slightly faster than that of the open clip, and the Mg clip maintained its efficacy in achieving vascular closure even after a 4-week period of immersion, indicating a commendable performance in secure ligation closure. In addition, the burst pressure test results showed that the staggered teeth clip exhibited a higher burst pressure (88.73 ± 2.58 kPa) with less mechanical damage occurring to the ligated vessels compared with the toothless clip, meeting the requirements for clinical application. Therefore, the newly developed R-shape Mg alloy clip, featuring staggered teeth, has demonstrated excellent mechanical stability and shows great promise in the application of biodegradable tissue clips.
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可生物降解 Mg-Nd-Zn-Zr 合金夹的结构优化和体外腐蚀分析
镁(Mg)合金具有生物可降解性和机械特性,为开发可降解止血夹提供了巨大潜力。然而,变形过程会导致应力集中,进而加快镁止血夹的腐蚀速度。本研究以 Mg-Nd-Zn-Zr 合金为基础,设计了无齿和交错齿两种结构特征的 R 形夹,并利用有限元分析(FEA)进行了模拟,通过浸泡试验和电化学测量研究了镁夹的腐蚀行为。此外,还通过爆破压力测试评估了镁夹的夹持性能。模拟结果表明,齿形交错的 R 型夹对血管造成的应力最小(1.237 兆帕)。夹紧变形过程结束后,闭合夹保持完好,没有任何开裂迹象。体外降解分析表明,闭合式夹子的腐蚀速度略快于开放式夹子,即使在浸泡 4 周后,镁夹子仍能保持其实现血管闭合的功效,这表明其在安全结扎闭合方面的性能值得称赞。此外,爆破压力测试结果表明,与无齿夹相比,交错齿夹的爆破压力更高(88.73 ± 2.58 kPa),结扎血管的机械损伤更小,符合临床应用要求。因此,新开发的具有交错齿的 R 形镁合金夹具有出色的机械稳定性,在生物可降解组织夹的应用中大有可为。
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来源期刊
Journal of the Mechanical Behavior of Biomedical Materials
Journal of the Mechanical Behavior of Biomedical Materials 工程技术-材料科学:生物材料
CiteScore
7.20
自引率
7.70%
发文量
505
审稿时长
46 days
期刊介绍: The Journal of the Mechanical Behavior of Biomedical Materials is concerned with the mechanical deformation, damage and failure under applied forces, of biological material (at the tissue, cellular and molecular levels) and of biomaterials, i.e. those materials which are designed to mimic or replace biological materials. The primary focus of the journal is the synthesis of materials science, biology, and medical and dental science. Reports of fundamental scientific investigations are welcome, as are articles concerned with the practical application of materials in medical devices. Both experimental and theoretical work is of interest; theoretical papers will normally include comparison of predictions with experimental data, though we recognize that this may not always be appropriate. The journal also publishes technical notes concerned with emerging experimental or theoretical techniques, letters to the editor and, by invitation, review articles and papers describing existing techniques for the benefit of an interdisciplinary readership.
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