Effect of Elevated Concentrations of Antibodies on the Immune Response in Patients with Autoimmune Thyroiditis

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2024-11-05 DOI:10.1134/S1990750823600565
K. V. Vereshchagina, A. V. Samodova, L. K. Dobrodeeva
{"title":"Effect of Elevated Concentrations of Antibodies on the Immune Response in Patients with Autoimmune Thyroiditis","authors":"K. V. Vereshchagina,&nbsp;A. V. Samodova,&nbsp;L. K. Dobrodeeva","doi":"10.1134/S1990750823600565","DOIUrl":null,"url":null,"abstract":"<p>A study is performed of the effect elevated concentrations of antibodies have on the immune response in patients with autoimmune thyroiditis (AIT) living in Arkhangelsk. Results from immunological examinations of 108 individuals with AIT are presented. The immunological study included examining hemograms, the contents of phenotypes of lymphocytes, cytokines, immunoglobulins, and antibodies of thyroid peroxidase (TPO), double-stranded DNA, and nucleoproteins. It was estanlished that a rise in the concentration of antibodies (AB) to TPO, ds-DNA, to RNP in patients with AIT is associated with elevated contents of mature T lymphocytes (CD3+), cytotoxic T lymphocytes (CD8+), cells labeled for programmed cell death (CD95+), and a drop in concentrations of IL-10. An increase in the concentration of cytotoxic lymphocytes and cells labeled for apoptosis and a simultaneous drop in the concentration of regulatory IL-10 is not beneficial in terms of prognostic value for the accumulation of autoantigens and autoantibodies.</p>","PeriodicalId":485,"journal":{"name":"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry","volume":"18 3","pages":"243 - 248"},"PeriodicalIF":0.6000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry","FirstCategoryId":"2","ListUrlMain":"https://link.springer.com/article/10.1134/S1990750823600565","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

A study is performed of the effect elevated concentrations of antibodies have on the immune response in patients with autoimmune thyroiditis (AIT) living in Arkhangelsk. Results from immunological examinations of 108 individuals with AIT are presented. The immunological study included examining hemograms, the contents of phenotypes of lymphocytes, cytokines, immunoglobulins, and antibodies of thyroid peroxidase (TPO), double-stranded DNA, and nucleoproteins. It was estanlished that a rise in the concentration of antibodies (AB) to TPO, ds-DNA, to RNP in patients with AIT is associated with elevated contents of mature T lymphocytes (CD3+), cytotoxic T lymphocytes (CD8+), cells labeled for programmed cell death (CD95+), and a drop in concentrations of IL-10. An increase in the concentration of cytotoxic lymphocytes and cells labeled for apoptosis and a simultaneous drop in the concentration of regulatory IL-10 is not beneficial in terms of prognostic value for the accumulation of autoantigens and autoantibodies.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
抗体浓度升高对自身免疫性甲状腺炎患者免疫反应的影响
对居住在阿尔汉格尔斯克的自身免疫性甲状腺炎(AIT)患者体内抗体浓度升高对免疫反应的影响进行了研究。本文介绍了对108名自身免疫性甲状腺炎患者进行免疫学检查的结果。免疫学研究包括检查血液图、淋巴细胞表型、细胞因子、免疫球蛋白、甲状腺过氧化物酶(TPO)抗体、双链DNA和核蛋白的含量。研究发现,AIT 患者体内 TPO、ds-DNA 和 RNP 抗体 (AB) 浓度的升高与成熟 T 淋巴细胞(CD3+)、细胞毒性 T 淋巴细胞(CD8+)、程序性细胞死亡标记细胞(CD95+)含量的升高以及 IL-10 浓度的下降有关。细胞毒性淋巴细胞和标记细胞凋亡的细胞浓度增加,同时调节性 IL-10 浓度下降,这对自身抗原和自身抗体积累的预后价值并无益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
1.10
自引率
0.00%
发文量
31
期刊介绍: Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry   covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.
期刊最新文献
Effect of Elevated Concentrations of Antibodies on the Immune Response in Patients with Autoimmune Thyroiditis Expression of miR-21, miR-378a, miR-205, and Their Targets in ER-Positive Breast Tumors with Different HER2 Protein Levels Construction of Expression Vectors for Efficient Production of Recombinant Proteins in E. coli for the Development of Therapeutic Drugs Effects of Various Poly(A) Tails on Luciferase Expression The Role of Arachidonic Acid Metabolizing Cytochromes P450 in the Control of Cardiovascular Functions
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1