Effect of Elevated Concentrations of Antibodies on the Immune Response in Patients with Autoimmune Thyroiditis

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2024-11-05 DOI:10.1134/S1990750823600565
K. V. Vereshchagina, A. V. Samodova, L. K. Dobrodeeva
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Abstract

A study is performed of the effect elevated concentrations of antibodies have on the immune response in patients with autoimmune thyroiditis (AIT) living in Arkhangelsk. Results from immunological examinations of 108 individuals with AIT are presented. The immunological study included examining hemograms, the contents of phenotypes of lymphocytes, cytokines, immunoglobulins, and antibodies of thyroid peroxidase (TPO), double-stranded DNA, and nucleoproteins. It was estanlished that a rise in the concentration of antibodies (AB) to TPO, ds-DNA, to RNP in patients with AIT is associated with elevated contents of mature T lymphocytes (CD3+), cytotoxic T lymphocytes (CD8+), cells labeled for programmed cell death (CD95+), and a drop in concentrations of IL-10. An increase in the concentration of cytotoxic lymphocytes and cells labeled for apoptosis and a simultaneous drop in the concentration of regulatory IL-10 is not beneficial in terms of prognostic value for the accumulation of autoantigens and autoantibodies.

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抗体浓度升高对自身免疫性甲状腺炎患者免疫反应的影响
对居住在阿尔汉格尔斯克的自身免疫性甲状腺炎(AIT)患者体内抗体浓度升高对免疫反应的影响进行了研究。本文介绍了对108名自身免疫性甲状腺炎患者进行免疫学检查的结果。免疫学研究包括检查血液图、淋巴细胞表型、细胞因子、免疫球蛋白、甲状腺过氧化物酶(TPO)抗体、双链DNA和核蛋白的含量。研究发现,AIT 患者体内 TPO、ds-DNA 和 RNP 抗体 (AB) 浓度的升高与成熟 T 淋巴细胞(CD3+)、细胞毒性 T 淋巴细胞(CD8+)、程序性细胞死亡标记细胞(CD95+)含量的升高以及 IL-10 浓度的下降有关。细胞毒性淋巴细胞和标记细胞凋亡的细胞浓度增加,同时调节性 IL-10 浓度下降,这对自身抗原和自身抗体积累的预后价值并无益处。
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来源期刊
CiteScore
1.10
自引率
0.00%
发文量
31
期刊介绍: Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry   covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.
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