Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling.

IF 6.9 1区 医学 Q1 CHEMISTRY, MULTIDISCIPLINARY Acta Pharmacologica Sinica Pub Date : 2024-11-06 DOI:10.1038/s41401-024-01413-6
Zheng-Jie Chia, Hirushi Kumarapperuma, Ruizhi Zhang, Peter J Little, Danielle Kamato
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Abstract

The Smad transcription factors are well known for their role at the core of transforming growth factor-β (TGF-β) signalling. However, recent evidence shows that the Smad transcription factors play a vital role downstream of other classes of receptors including G protein-coupled receptors (GPCR). The versatility of Smad transcription factors originated from the two regions that can be differently activated by the TGF-β receptor superfamily or through the recruitment of intracellular kinases stimulated by other receptors classes such as GPCRs. The classic GPCR signalling cascade is further expanded to conditional adoption of the Smad transcription factor under the stimulation of Akt, demonstrating the unique involvement of the Smad transcription factor in GPCR signalling pathways in disease environments. In this review, we provide a summary of the signalling pathways of the Smad transcription factors as an important downstream mediator of GPCRs, presenting exciting opportunities for discovering new therapeutic targets for diseases.

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Smad 转录因子是 7 跨膜 G 蛋白偶联受体信号的媒介。
众所周知,Smad 转录因子是转化生长因子-β(TGF-β)信号传导的核心。然而,最近的证据表明,Smad 转录因子在其他类型受体(包括 G 蛋白偶联受体(GPCR))的下游也发挥着重要作用。Smad 转录因子的多功能性源于它的两个区域,这两个区域可被 TGF-β 受体超家族或通过招募受 GPCR 等其他受体刺激的细胞内激酶以不同方式激活。经典的 GPCR 信号级联进一步扩展到在 Akt 的刺激下有条件地采用 Smad 转录因子,这表明了 Smad 转录因子在疾病环境中参与 GPCR 信号通路的独特性。在这篇综述中,我们总结了作为 GPCR 重要下游介质的 Smad 转录因子的信号通路,为发现新的疾病治疗靶点提供了令人兴奋的机会。
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来源期刊
Acta Pharmacologica Sinica
Acta Pharmacologica Sinica 医学-化学综合
CiteScore
15.10
自引率
2.40%
发文量
4365
审稿时长
2 months
期刊介绍: APS (Acta Pharmacologica Sinica) welcomes submissions from diverse areas of pharmacology and the life sciences. While we encourage contributions across a broad spectrum, topics of particular interest include, but are not limited to: anticancer pharmacology, cardiovascular and pulmonary pharmacology, clinical pharmacology, drug discovery, gastrointestinal and hepatic pharmacology, genitourinary, renal, and endocrine pharmacology, immunopharmacology and inflammation, molecular and cellular pharmacology, neuropharmacology, pharmaceutics, and pharmacokinetics. Join us in sharing your research and insights in pharmacology and the life sciences.
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