[Association Between Triglyceride Glucose Index and Triglyceride Glucose-Obesity Composite Indices and the Risk of Ischemic Heart Disease].

Q3 Medicine 四川大学学报(医学版) Pub Date : 2024-09-20 DOI:10.12182/20240960103

Jing Yang, Chenyan Zhu, Lu Yuan, Tao Zhang, Jiayuan Li, Xia Jiang, Lu Long, Jiaqiang Liao, Tianpei Ma, West China Health And Aging Chronic Disease Preventive And Treatment Merging Study Wchac Collaborative Group

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Abstract

Objective: To explore the association between the triglyceride-glucose index (TyG) and TyG-obesity composite indices, including TyG-waist circumference (TyG-WC), TyG-body mass index (TyG-BMI), and TyG-waist-to-height ratio (TyG-WHtR), and the risk of ischemic heart disease (IHD), and to provide reference for the prevention of IHD.

Methods: The sample of this study was derived from the West China Elderly Preventive and Treatment Merging Cohort, from which 9628 elderly individuals from the retrospective cohort were selected. Cox regression models were used to analyze the association between TyG-related indices and the risk of IHD. Receiver operating characteristic (ROC) curves were plotted to assess and compare the performance of TyG-related indices in predicting the occurrence of IHD.

Results: The participants were followed up for a median of 2.82 years, with 7.2% (694/9628) of the participants experiencing IHD events. Multivariate Cox regression showed that after controlling for the covariates, including sex, age, educational attainment, smoking, drinking, exercise, dietary habits, medication history, and whether the participant had hypertension, every time TyG, TyG-WC, TyG-BMI and TyG-WHtR increased by one standard deviation (SD), the risk of IHD increased by 12% (hazard ratio [HR]=1.12, 95% confidence interval [CI]: 1.04-1.20), 21% (HR=1.21, 95% CI: 1.12-1.31), 20% (HR=1.20, 95% CI: 1.12-1.29), and 19% (HR=1.19, 95% CI: 1.10-1.28), respectively. Both the TyG index and TyG-obesity composite indices were positively correlated with IHD risk, showing a linear relationship (P<0.05). TyG-WC (area under the curve[AUC]=0.680, 95% CI: 0.660-0.700, P<0.001), TyG-BMI (AUC=0.674, 95% CI: 0.654-0.695, P<0.001), and TyG-WHtR (AUC=0.678, 95% CI: 0.658-0.698, P<0.001) demonstrated better predictive performance than TyG did (AUC=0.669, 95% CI: 0.648-0.689, P<0.001).

Conclusion: Elevated levels of TyG and TyG-obesity composite indices were associated with a higher risk for IHD, and combining TyG with BMI, WC, and WHtR may lead to better performance in risk assessment for IHD than using TyG alone.

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[甘油三酯血糖指数和甘油三酯血糖-肥胖综合指数与缺血性心脏病风险之间的关系]。

目的探讨甘油三酯-葡萄糖指数（TyG）和TyG-肥胖综合指数（包括TyG-腰围（TyG-WC）、TyG-体重指数（TyG-BMI）和TyG-腰围-身高比（TyG-WHtR））与缺血性心脏病（IHD）风险的关系，为IHD的预防提供参考：本研究的样本来自华西老年防治合并队列，从回顾性队列中选取了9628名老年人。采用Cox回归模型分析TyG相关指数与IHD风险之间的关系。绘制了接收者操作特征曲线（ROC），以评估和比较TyG相关指数在预测IHD发生方面的性能：对参与者的随访时间中位数为2.82年，其中7.2%（694/9628）的参与者发生了IHD事件。多变量考克斯回归显示，在控制了包括性别、年龄、教育程度、吸烟、饮酒、运动、饮食习惯、用药史和是否患有高血压在内的协变量后，TyG、TyG-WC、TyG-BMI和TyG-WHtR每增加一个标准差（SD），发生心肌梗死的风险就会增加12%（危险比[HR]=1.12，95% 置信区间[CI]：1.04-1.20）、21%（HR=1.21，95% CI：1.12-1.31）、20%（HR=1.20，95% CI：1.12-1.29）和 19%（HR=1.19，95% CI：1.10-1.28）。TyG指数和TyG-肥胖综合指数均与IHD风险呈正相关，呈现线性关系（PPPPP结论：TyG和TyG-肥胖综合指数水平升高与IHD风险升高相关，将TyG与BMI、WC和WHtR结合起来可能比单独使用TyG更有利于IHD风险评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

四川大学学报(医学版) Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

0.70

自引率

0.00%

发文量

8695

期刊介绍： "Journal of Sichuan University (Medical Edition)" is a comprehensive medical academic journal sponsored by Sichuan University, a higher education institution directly under the Ministry of Education of the People's Republic of China. It was founded in 1959 and was originally named "Journal of Sichuan Medical College". In 1986, it was renamed "Journal of West China University of Medical Sciences". In 2003, it was renamed "Journal of Sichuan University (Medical Edition)" (bimonthly). "Journal of Sichuan University (Medical Edition)" is a Chinese core journal and a Chinese authoritative academic journal (RCCSE). It is included in the retrieval systems such as China Science and Technology Papers and Citation Database (CSTPCD), China Science Citation Database (CSCD) (core version), Peking University Library's "Overview of Chinese Core Journals", the U.S. "Index Medica" (IM/Medline), the U.S. "PubMed Central" (PMC), the U.S. "Biological Abstracts" (BA), the U.S. "Chemical Abstracts" (CA), the U.S. EBSCO, the Netherlands "Abstracts and Citation Database" (Scopus), the Japan Science and Technology Agency Database (JST), the Russian "Abstract Magazine", the Chinese Biomedical Literature CD-ROM Database (CBMdisc), the Chinese Biomedical Periodical Literature Database (CMCC), the China Academic Journal Network Full-text Database (CNKI), the Chinese Academic Journal (CD-ROM Edition), and the Wanfang Data-Digital Journal Group.