Effect of reduced saturation and elevated D-dimer and interleukin 6 levels on vessel density and foveal avascular zone in patients with COVID-19 bilateral pneumonia.

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL Advances in Clinical and Experimental Medicine Pub Date : 2024-11-07 DOI:10.17219/acem/191774
Magdalena Kal, Michał Brzdęk, Elżbieta Cieśla, Piotr Rzymski, Izabella Karska-Basta, Antonio Pinna, Jerzy Mackiewicz, Mateusz Winiarczyk, Dominik Odrobina, Dorota Zarębska-Michaluk
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Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can affect multiple organs, including the eyes.

Objectives: This study aimed to identify associations between vascular density (VD) and the foveal avascular zone (FAZ), assessed using optical coherence tomography angiography (OCTA), and baseline levels of D-dimers and interleukin 6 (IL-6) in patients with bilateral COVID-19 pneumonia, depending on oxygen saturation (SpO2) on admission.

Material and methods: The study included patients with COVID-19 bilateral pneumonia due to SARS-CoV-2 infection who were hospitalized between March and May 2021. Ophthalmological examination was performed 2 months after hospitalization. Optical coherence tomography angiography was used for the automatic assessment of the central retinal VD and the manual assessment of FAZ.

Results: A significant monotonic negative relationship was observed between SpO2 . 90% and VD in some areas of the superficial capillary plexus (SCP) (p = 0.048) and choriocapillaris (p = 0.021), and the mean VD in the deep capillary plexus (DCP) (p = 0.048). No significant monotonic negative relationship was noted between SpO2 . 90% and the FAZ in the SCP (p = 0.075). However, there was a significant monotonic positive relationship between VD in the nasal choriocapillaris and D-dimer levels in patients with SpO2 . 90% (p = 0.003, respectively). Finally, a monotonic negative relationship was identified between foveal VD in the DCP and IL-6 levels in patients with SpO2 . 90% (p = 0.027).

Conclusions: An OCTA study conducted 2 months after hospitalization for COVID-19 bilateral pneumonia showed reduced VD in those with SpO2 . 90% and elevated levels of D-dimers and IL-6 during hospitalization. Optical coherence tomography angiography testing can provide monitoring of ocular status in patients following SARS-CoV-2 infection, especially those who report visual disturbances.

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饱和度降低、D-二聚体和白细胞介素 6 水平升高对 COVID-19 双侧肺炎患者血管密度和眼窝无血管区的影响。
背景:严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染可影响多个器官,包括眼睛:严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)感染可影响多个器官,包括眼睛:本研究旨在根据入院时的血氧饱和度(SpO2),确定双侧 COVID-19 肺炎患者的血管密度(VD)和眼窝无血管区(FAZ)(使用光学相干断层血管造影术(OCTA)评估)与 D 二聚体和白细胞介素 6(IL-6)基线水平之间的关系:研究对象为 2021 年 3 月至 5 月期间住院的因感染 SARS-CoV-2 而患 COVID-19 双侧肺炎的患者。住院 2 个月后进行眼科检查。光学相干断层血管造影术用于自动评估视网膜中央VD和手动评估FAZ:结果:SpO2 .结果:SpO2.90%与浅层毛细血管丛(SCP)(p = 0.048)和绒毛膜(p = 0.021)部分区域的 VD 以及深层毛细血管丛(DCP)的平均 VD 之间存在明显的单调负相关(p = 0.048)。SpO2 .90% 和 SCP 中的 FAZ 之间没有明显的单调负相关关系(p = 0.075)。然而,SpO2 .90%的患者的鼻腔绒毛膜 VD 与 D-二聚体水平之间存在明显的单调正相关关系(分别为 p = 0.003)。最后,在 SpO2 .结论:COVID-19双侧肺炎患者住院2个月后进行的OCTA研究显示,SpO2 .结论:在 COVID-19 双侧肺炎住院 2 个月后进行的 OCTA 研究显示,SpO2 为 90% 的患者 VD 降低,住院期间 D-二聚体和 IL-6 水平升高。光学相干断层血管成像检测可监测感染 SARS-CoV-2 后患者的眼部状况,尤其是那些报告有视力障碍的患者。
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来源期刊
Advances in Clinical and Experimental Medicine
Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.70
自引率
4.80%
发文量
153
审稿时长
6-12 weeks
期刊介绍: Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.
期刊最新文献
Effect of reduced saturation and elevated D-dimer and interleukin 6 levels on vessel density and foveal avascular zone in patients with COVID-19 bilateral pneumonia. Sex-related differences in the association of obesity described by emergency medical teams on outcomes in out-of-hospital cardiac arrest patients. Acute kidney injury during transplantation and the role of inflammasomes: A brief review. An umbrella analysis assessing the risk of acute kidney injury in COVID-19 patients. Effectiveness of phentolamine mesylate, vibration and photobiomodulation in reducing pain and the reversal of local anesthesia: A systematic review.
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