The Effect and Clinical Implications of IL-1β on the Development of Aneurysmal Subarachnoid Hemorrhage.

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Clinical laboratory Pub Date : 2024-11-01 DOI:10.7754/Clin.Lab.2024.240608

Feng Li, Weifeng Zhang, Ming Wang, Pifeng Jia

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Abstract

Background: This study aimed to investigate the effect and clinical implications of IL-1β on the development of aneurysmal subarachnoid hemorrhage.

Methods: This retrospective study included a total of 80 participants, and these participants were divided into the following two groups: control group (healthy participants) and experimental group (aneurysmal subarachnoid hemorrhage patients). Then, all of the participants received digital subtraction angiography or computed tomography angiography. Participants' general data were collected and analyzed. IL-1β expression in blood samples were determined by ELISA, and then IL-1β protein were determined by western blotting.

Results: A total of 80 participants was included in this study, and the participants` general data, including gender, age, and previous medical history, showed no significant differences between the experimental group and control group. The IL-1β value in the experimental group was significantly increased, and the difference was statistically significant (p < 0.05).

Conclusions: Upregulated IL-1β can promote the development of aneurysmal subarachnoid hemorrhage, indicating that IL-1β is a key factor in evaluating the prognosis of patients with aneurysmal subarachnoid hemorrhage.

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IL-1β对动脉瘤性蛛网膜下腔出血的影响及临床意义

背景：本研究旨在探讨IL-1β对动脉瘤性蛛网膜下腔出血的影响及其临床意义：本研究旨在探讨IL-1β对动脉瘤性蛛网膜下腔出血的影响及临床意义：这项回顾性研究共纳入了 80 名参与者，这些参与者被分为以下两组：对照组（健康参与者）和实验组（动脉瘤性蛛网膜下腔出血患者）。然后，所有参与者都接受了数字减影血管造影术或计算机断层扫描血管造影术。收集并分析了参与者的一般数据。用 ELISA 法测定血液样本中 IL-1β 的表达，然后用 Western 印迹法测定 IL-1β 蛋白：实验组与对照组的性别、年龄、既往病史等一般资料无显著差异。实验组的 IL-1β 值明显升高，差异有统计学意义（P < 0.05）：结论：IL-1β上调可促进动脉瘤性蛛网膜下腔出血的发展，表明IL-1β是评估动脉瘤性蛛网膜下腔出血患者预后的关键因素。

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.