The Impact of Cognitive Behavioral Therapy for Insomnia on Neurofilament Light and Phosphorylated Tau in Individuals with a Concussion.

IF 2.1 4区心理学 Q2 PSYCHOLOGY Archives of Clinical Neuropsychology Pub Date : 2024-11-06 DOI:10.1093/arclin/acae096

Rebecca Ludwig, Michael Rippee, Linda D'Silva, Jeff Radel, Aaron M Eakman, Jill Morris, Alvin Beltramo, Michelle Drerup, Catherine Siengsukon

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Abstract

Background: Concussions damage neurologic tissue, increasing release of intercellular proteins including phosphorylated Tau (pTau) and neurofilament light (NfL). Disrupted sleep from a concussion negatively impacts the ability of the glymphatic system to remove cellular waste from the brain.

Objective: The purpose of this study was to determine if enhancing sleep using Cognitive Behavioral Therapy for Insomnia (CBT-I) impacts pTau and NFL levels following a concussion.

Methods: This is pre/post intervention analysis of a larger wait-list control study. Participants had their blood sampled pre/post the CBT-I intervention which was analyzed using SIMOA analytics. Paired sampling statistics and linear regression models were used to examine how insomnia severity impacts pTau181 and NfL.

Results: Twenty-eight participants were enrolled in this study. Age and baseline protein level were significantly associated with post-intervention protein levels, but post-intervention insomnia severity was not associated with post-intervention protein levels. About 50% of participants that had clinically meaningful change in insomnia and had a reduction in their NfL and pTau181 values.

Conclusions: Post-intervention insomnia was not associated with post-intervention NfL or pTau. Yet, on an individual level, ~50% of participants had a clinically meaningful change in insomnia and reduced level of NfL and pTau 18.1.

Clinical trial registration: NCT04885205 https://clinicaltrials.gov.

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失眠症认知行为疗法对脑震荡患者神经丝光和磷酸化 Tau 的影响

背景：脑震荡会损伤神经组织，增加细胞间蛋白的释放，包括磷酸化 Tau（pTau）和神经丝光（NfL）。脑震荡导致的睡眠中断会对甘油系统清除脑内细胞废物的能力产生负面影响：本研究旨在确定使用失眠认知行为疗法（CBT-I）改善睡眠是否会影响脑震荡后的 pTau 和 NFL 水平：这是一项大型等待名单对照研究的干预前后分析。参与者在接受 CBT-I 干预前后进行了血液采样，并使用 SIMOA 分析方法进行了分析。使用配对抽样统计和线性回归模型来研究失眠严重程度如何影响 pTau181 和 NfL：本研究共招募了 28 名参与者。年龄和基线蛋白质水平与干预后的蛋白质水平有显著关联，但干预后的失眠严重程度与干预后的蛋白质水平无关。约50%的参与者在失眠方面发生了有临床意义的变化，其NfL和pTau181值也有所下降：结论：干预后失眠与干预后 NfL 或 pTau 无关。结论：干预后的失眠与干预后的NfL和pTau值无关。然而，就个体而言，约50%的参与者的失眠发生了有临床意义的改变，NfL和pTau18.1的水平也有所下降：NCT04885205 https://clinicaltrials.gov。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Clinical Neuropsychology 医学-心理学

CiteScore

4.60

自引率

7.70%

发文量

358

审稿时长

6-12 weeks

期刊介绍： The journal publishes original contributions dealing with psychological aspects of the etiology, diagnosis, and treatment of disorders arising out of dysfunction of the central nervous system. Archives of Clinical Neuropsychology will also consider manuscripts involving the established principles of the profession of neuropsychology: (a) delivery and evaluation of services, (b) ethical and legal issues, and (c) approaches to education and training. Preference will be given to empirical reports and key reviews. Brief research reports, case studies, and commentaries on published articles (not exceeding two printed pages) will also be considered. At the discretion of the editor, rebuttals to commentaries may be invited. Occasional papers of a theoretical nature will be considered.