Cutting-edge insights into Helicobacter research.

IF 3.6 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Free Radical Research Pub Date : 2024-11-06 DOI:10.1080/10715762.2024.2421174
Hideki Mori, Hidekazu Suzuki
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引用次数: 0

Abstract

Non-Helicobacter pylori Helicobacter (NHPH) species are emerging as significant gastric pathogens. Despite their clinical importance, NHPH infections are less studied compared to Helicobacter pylori (H. pylori) due to their lower prevalence and diagnostic challenges. Zoonotic transmission, particularly from pigs, dogs, and cats, underscores the need for improved diagnostic methods and heightened clinical awareness. Gastric cancer (GC) remains a major global health issue, with H. pylori being a primary risk factor. The eradication of H. pylori reduces GC risk, but post-eradication surveillance is essential. Endoscopic findings, especially those from the Kyoto classification, and noninvasive biomarkers play crucial roles in early GC detection and risk assessment. The increasing antibiotic resistance in H. pylori necessitates new treatment strategies. Novel therapies, such as vonoprazan-based regimens, and alternatives like sitafloxacin and rifabutin, are being developed to improve eradication success rates. Understanding the fundamental mechanisms of gastric carcinogenesis, including the roles of oxidative stress and cancer stem cells, is key to advancing treatment. Targeting specific molecular pathways offers potential for more effective therapies.

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对螺旋杆菌研究的前沿见解。
非幽门螺旋杆菌(NHPH)正在成为重要的胃部病原体。尽管 NHPH 感染具有重要的临床意义,但与幽门螺旋杆菌(H. pylori)相比,由于其发病率较低且诊断困难,对其的研究较少。人畜共患病传播,尤其是猪、狗和猫的传播,凸显了改进诊断方法和提高临床意识的必要性。胃癌(GC)仍然是全球主要的健康问题,幽门螺杆菌是主要的风险因素。根除幽门螺杆菌可降低胃癌风险,但根除后的监测至关重要。内镜检查结果(尤其是京都分类法)和无创生物标志物在早期 GC 检测和风险评估中发挥着至关重要的作用。幽门螺杆菌的抗生素耐药性越来越强,因此有必要采取新的治疗策略。为了提高根除幽门螺杆菌的成功率,目前正在开发新的治疗方法,如基于vonoprazan的治疗方案,以及西他沙星和利福布汀等替代品。了解胃癌发生的基本机制,包括氧化应激和癌症干细胞的作用,是推进治疗的关键。针对特定的分子通路可提供更有效的疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Free Radical Research
Free Radical Research 生物-生化与分子生物学
CiteScore
6.70
自引率
0.00%
发文量
47
审稿时长
3 months
期刊介绍: Free Radical Research publishes high-quality research papers, hypotheses and reviews in free radicals and other reactive species in biological, clinical, environmental and other systems; redox signalling; antioxidants, including diet-derived antioxidants and other relevant aspects of human nutrition; and oxidative damage, mechanisms and measurement.
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