Prognostic value of neutrophil-to-lymphocyte ratio in patients with non-muscle-invasive bladder cancer with intravesical Bacillus Calmette-Guérin immunotherapy: a systematic review and meta-analysis.

IF 5.7 2区医学 Q1 IMMUNOLOGY Frontiers in Immunology Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.3389/fimmu.2024.1464635

Jiaguo Huang, Li Lin, Dikai Mao, Runmiao Hua, Feifei Guan

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Abstract

Background: The predictive accuracy of the preoperative neutrophil-to-lymphocyte ratio (NLR) on the prognosis of patients with non-muscle-invasive bladder cancer (NMIBC) with intravesical Bacillus Calmette-Guérin immunotherapy (BCG) after transurethral resection of the bladder tumor (TURBT) remains unknown. Therefore, the current study performed a systematic review and meta-analysis to examine the relationship between preoperative NLR and the prognosis of patients with NMIBC with intravesical BCG immunotherapy.

Methods: For this systematic review and meta-analysis, articles were retrieved from PubMed, Cochrane Library, Web of Science, and Embase databases from their inception to 14 May 2024. The role of NLR in predicting recurrence and progression in NMIBC was determined using pooled hazard ratios (HRs) and 95% confidence intervals (CIs).

Results: Seven articles were included in this meta-analysis, involving 4,187 patients. An elevated NLR was significantly associated with recurrence (HR = 2.67, 95% CI = 1.34-5.32, P < 0.001) and progression (HR = 1.72, 95% CI = 1.13-2.60, P = 0.004) in patients with NMIBC with intravesical BCG immunotherapy.

Conclusion: This meta-analysis demonstrated that elevated preoperative NLR levels were significantly associated with recurrence and disease progression in patients with NMIBC who underwent intravesical BCG immunotherapy after TURBT.

Systematic review registration: https://inplasy.com/inplasy-2024-7-0058/, identifier 202470058.

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膀胱内卡介苗免疫疗法非肌层浸润性膀胱癌患者中性粒细胞与淋巴细胞比值的预后价值：系统综述与荟萃分析。

背景：经尿道膀胱肿瘤切除术（TURBT）后接受卡介苗免疫疗法（BCG）的非肌层浸润性膀胱癌（NMIBC）患者术前中性粒细胞与淋巴细胞比值（NLR）对其预后的预测准确性尚不清楚。因此，本研究进行了一项系统综述和荟萃分析，以探讨接受膀胱内卡介苗免疫疗法的 NMIBC 患者术前 NLR 与预后之间的关系：本系统综述和荟萃分析从PubMed、Cochrane Library、Web of Science和Embase数据库中检索了从开始到2024年5月14日的文章。采用汇总的危险比（HRs）和95%置信区间（CIs）确定NLR在预测NMIBC复发和进展中的作用：本次荟萃分析共纳入七篇文章，涉及4187名患者。在接受膀胱内卡介苗免疫疗法的 NMIBC 患者中，NLR 升高与复发（HR = 2.67，95% CI = 1.34-5.32，P < 0.001）和病情进展（HR = 1.72，95% CI = 1.13-2.60，P = 0.004）显著相关：该荟萃分析表明，在TURBT后接受膀胱内卡介苗免疫治疗的NMIBC患者中，术前NLR水平升高与复发和疾病进展显著相关。系统综述注册：https://inplasy.com/inplasy-2024-7-0058/，标识符202470058。

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.