Effect of preoperative oral cannabidiol-rich Cannabis extract on anxiety and postoperative pain after endodontic treatment: A double-blind randomized clinical trial.

IF 3.5 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Journal of endodontics Pub Date : 2024-11-04 DOI:10.1016/j.joen.2024.10.010
Silmara de Andrade Silva, Christianne Velozo, Luiza de Almeida Souto Montenegro, Wesley Viana de Sousa, Marina da Cunha Isaltino, Margareth de Fátima Formiga Melo Diniz, Diana Santana de Albuquerque
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Abstract

Introduction: The aim of the present study was to evaluate the effectiveness of cannabidiol-rich Cannabis extract in reducing anxiety and postoperative pain in patients submitted to endodontic treatment METHODS: The study was carried out after approval by the Research Ethics Committee (Registration No. 5.075.961). The following groups were tested: cannabidiol (CBD) and placebo. Pain was measured using a Visual Analog Scale (VAS) before the start of treatment and 24, 48 and 72 h and 7 days after the session. Anxiety was assessed using the Modified Dental Anxiety Scale and a VAS, before and immediately after treatment. In addition, salivary cortisol was measured before drug administration and after anesthesia. Data were analyzed descriptively using absolute frequencies and percentages, with a 5% margin of error.

Results: The mean anxiety scores were higher in the Cannabidiol group than in the placebo group in each assessment (pre: 5.06 versus 3.07, respectively; post: 4.61 versus 2.60). However, there was no significant difference in the reduction of dental anxiety at the beginning of the consultation and throughout the procedure. We did not find statistically significant differences in postoperative pain between the Cannabidiol and placebo groups at any of the time points.

Conclusion: There was no evidence of an exposure-response relationship between the intervention and control groups. However, more studies are needed to determine clinical outcomes.

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术前口服富含大麻二酚的大麻提取物对牙髓治疗后焦虑和术后疼痛的影响:双盲随机临床试验。
简介本研究旨在评估富含大麻二酚的大麻提取物在减轻牙髓治疗患者的焦虑和术后疼痛方面的效果 方法:本研究经研究伦理委员会(注册号:5.075.961)批准后进行。试验分为以下几组:大麻二酚(CBD)组和安慰剂组。在治疗开始前、治疗后 24、48、72 小时和 7 天内,使用视觉模拟量表 (VAS) 测量疼痛。在治疗前和治疗后立即使用改良牙科焦虑量表和 VAS 对焦虑进行评估。此外,还在用药前和麻醉后测量了唾液皮质醇。数据采用绝对频率和百分比进行描述性分析,误差率为 5%:在每次评估中,大麻二酚组的平均焦虑评分均高于安慰剂组(前:分别为 5.06 对 3.07;后:分别为 4.61 对 2.60)。然而,在咨询开始时和整个过程中,牙科焦虑的减轻程度没有明显差异。在任何一个时间点,我们都没有发现大麻二酚组和安慰剂组在术后疼痛方面有明显的统计学差异:结论:没有证据表明干预组和对照组之间存在暴露-反应关系。但是,还需要更多的研究来确定临床结果。
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来源期刊
Journal of endodontics
Journal of endodontics 医学-牙科与口腔外科
CiteScore
8.80
自引率
9.50%
发文量
224
审稿时长
42 days
期刊介绍: The Journal of Endodontics, the official journal of the American Association of Endodontists, publishes scientific articles, case reports and comparison studies evaluating materials and methods of pulp conservation and endodontic treatment. Endodontists and general dentists can learn about new concepts in root canal treatment and the latest advances in techniques and instrumentation in the one journal that helps them keep pace with rapid changes in this field.
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