Cerebral biomimetic nano-drug delivery systems: A frontier strategy for immunotherapy

IF 10.5 1区医学 Q1 CHEMISTRY, MULTIDISCIPLINARY Journal of Controlled Release Pub Date : 2024-11-08 DOI:10.1016/j.jconrel.2024.10.058

Hao Tian , Jiaxin Yao , Qi Ba , Yuanyuan Meng , Yanan Cui , Liangzhu Quan , Wei Gong , Yuli Wang , Yang Yang , Meiyan Yang , Chunsheng Gao

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Abstract

Brain diseases are a significant threat to human health, especially in the elderly, and this problem is growing as the aging population increases. Efficient brain-targeted drug delivery has been the greatest challenge in treating brain disorders due to the unique immune environment of the brain, including the blood-brain barrier (BBB). Recently, cerebral biomimetic nano-drug delivery systems (CBNDSs) have provided a promising strategy for brain targeting by mimicking natural biological materials. Herein, this review explores the latest understanding of the immune microenvironment of the brain, emphasizing the immune mechanisms of the occurrence and progression of brain disease. Several brain targeting systems are summarized, including cell-based, exosome-based, protein-based, and microbe-based CBNDSs, and their immunological mechanisms are highlighted. Moreover, given the rise of immunotherapy, the latest applications of CBNDSs in immunotherapy are also discussed. This review provides a comprehensive understanding of CBNDSs and serves as a guideline for immunotherapy in treating brain diseases. In addition, it provides inspiration for the future of CBNDSs.

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脑生物仿生纳米给药系统：免疫疗法的前沿策略

脑部疾病是人类健康的重大威胁，尤其是在老年人中，而且随着老龄化人口的增加，这一问题正在日益严重。由于大脑独特的免疫环境，包括血脑屏障（BBB），高效的脑靶向给药一直是治疗脑部疾病的最大挑战。最近，脑生物仿生纳米给药系统（CBNDS）通过模仿天然生物材料，为脑靶向给药提供了一种前景广阔的策略。本综述探讨了对脑部免疫微环境的最新认识，强调了脑部疾病发生和发展的免疫机制。综述了几种脑靶向系统，包括基于细胞的、基于外泌体的、基于蛋白质的和基于微生物的 CBNDS，并重点介绍了它们的免疫学机制。此外，鉴于免疫疗法的兴起，还讨论了 CBNDS 在免疫疗法中的最新应用。这篇综述提供了对 CBNDS 的全面了解，可作为治疗脑部疾病的免疫疗法指南。此外，它还为 CBNDS 的未来发展提供了启示。

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来源期刊

Journal of Controlled Release 医学-化学综合

CiteScore

18.50

自引率

5.60%

发文量

700

审稿时长

39 days

期刊介绍： The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.