Assessment of health impacts in retired antisera-producing horses: Blood biochemistry and serum amyloid A analysis.

IF 1.7 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Veterinary World Pub Date : 2024-09-01 Epub Date: 2024-09-20 DOI:10.14202/vetworld.2024.2136-2143
Dinar Arifianto, Anita Esfandiari, I Wayan Teguh Wibawan, Amrozi Amrozi, Maharani Maharani, Darsono Darsono, Hirawan Setiadi, Agus Setiyono
{"title":"Assessment of health impacts in retired antisera-producing horses: Blood biochemistry and serum amyloid A analysis.","authors":"Dinar Arifianto, Anita Esfandiari, I Wayan Teguh Wibawan, Amrozi Amrozi, Maharani Maharani, Darsono Darsono, Hirawan Setiadi, Agus Setiyono","doi":"10.14202/vetworld.2024.2136-2143","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aim: </strong>Horses used for antisera production are repeatedly hyperimmunized to produce high levels of specific antibodies. This prolonged process can lead to various health issues, including amyloidosis, which involves the accumulation of amyloid proteins in organs and tissues, potentially causing organ dysfunction and failure. These horses are often retired when they no longer produce adequate antibody levels. This study aimed to evaluate the impact of prolonged antisera production on the health of retired horses by examining their blood biochemistry and serum amyloid A (SAA) levels, which are indicators of systemic inflammation and organ damage.</p><p><strong>Materials and methods: </strong>Blood samples were collected from 12 horses for this study. Nine horses were retired antisera-producing horses that had been discontinued for 2 years, while three healthy non-antisera-producing horses were used as controls. These twelve horses were divided into four groups based on the duration of their active period as antisera producers (never been used, 2-3 years, 4-5 years, and 6-7 years). We measured key blood biochemistry parameters and SAA levels to evaluate the health status of the horses.</p><p><strong>Results: </strong>Total protein, fibrinogen, and globulin levels were elevated, whereas other parameters remained normal. The findings indicate that despite normal SAA levels, the horses exhibited signs of ongoing health issues related to their previous use in antisera production, such as increased total plasma protein, fibrinogen, and globulin levels, as well as the presence of amyloid deposits in vital organs such as the liver and kidneys, as observed in post-mortem examinations.</p><p><strong>Conclusion: </strong>Despite normal SAA levels, retired antisera-producing horses showed elevated total protein, fibrinogen, and globulin levels, indicating ongoing health issues.</p>","PeriodicalId":23587,"journal":{"name":"Veterinary World","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536727/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary World","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14202/vetworld.2024.2136-2143","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/20 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0

Abstract

Background and aim: Horses used for antisera production are repeatedly hyperimmunized to produce high levels of specific antibodies. This prolonged process can lead to various health issues, including amyloidosis, which involves the accumulation of amyloid proteins in organs and tissues, potentially causing organ dysfunction and failure. These horses are often retired when they no longer produce adequate antibody levels. This study aimed to evaluate the impact of prolonged antisera production on the health of retired horses by examining their blood biochemistry and serum amyloid A (SAA) levels, which are indicators of systemic inflammation and organ damage.

Materials and methods: Blood samples were collected from 12 horses for this study. Nine horses were retired antisera-producing horses that had been discontinued for 2 years, while three healthy non-antisera-producing horses were used as controls. These twelve horses were divided into four groups based on the duration of their active period as antisera producers (never been used, 2-3 years, 4-5 years, and 6-7 years). We measured key blood biochemistry parameters and SAA levels to evaluate the health status of the horses.

Results: Total protein, fibrinogen, and globulin levels were elevated, whereas other parameters remained normal. The findings indicate that despite normal SAA levels, the horses exhibited signs of ongoing health issues related to their previous use in antisera production, such as increased total plasma protein, fibrinogen, and globulin levels, as well as the presence of amyloid deposits in vital organs such as the liver and kidneys, as observed in post-mortem examinations.

Conclusion: Despite normal SAA levels, retired antisera-producing horses showed elevated total protein, fibrinogen, and globulin levels, indicating ongoing health issues.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
评估退役抗血清生产马的健康影响:血液生化和血清淀粉样蛋白 A 分析。
背景和目的:用于生产抗血清的马匹要反复进行过度免疫,以产生高水平的特异性抗体。这种长期的过程会导致各种健康问题,包括淀粉样变性,即淀粉样蛋白在器官和组织中积累,可能导致器官功能障碍和衰竭。当这些马匹不再产生足够的抗体水平时,它们通常会退役。本研究旨在通过检测退役马的血液生化指标和血清淀粉样蛋白A(SAA)水平,评估长期产生抗血清对退役马健康的影响:本研究采集了 12 匹马的血液样本。九匹马是停产两年的退役抗血清生产马,三匹健康的非抗血清生产马作为对照。这 12 匹马根据它们作为抗血清生产者的活跃期(从未使用过、2-3 年、4-5 年和 6-7 年)分为四组。我们测量了主要的血液生化指标和 SAA 水平,以评估马匹的健康状况:结果:总蛋白、纤维蛋白原和球蛋白水平升高,而其他参数保持正常。研究结果表明,尽管这些马的 SAA 水平正常,但它们仍表现出与以前用于生产抗血清有关的持续健康问题,如血浆总蛋白、纤维蛋白原和球蛋白水平升高,以及在肝脏和肾脏等重要器官中出现淀粉样沉积物,这些都是在死后检查中观察到的:结论:尽管SAA水平正常,但退役抗血清产生马的总蛋白、纤维蛋白原和球蛋白水平升高,表明健康问题仍在持续。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Veterinary World
Veterinary World Multiple-
CiteScore
3.60
自引率
12.50%
发文量
317
审稿时长
16 weeks
期刊介绍: Veterinary World publishes high quality papers focusing on Veterinary and Animal Science. The fields of study are bacteriology, parasitology, pathology, virology, immunology, mycology, public health, biotechnology, meat science, fish diseases, nutrition, gynecology, genetics, wildlife, laboratory animals, animal models of human infections, prion diseases and epidemiology. Studies on zoonotic and emerging infections are highly appreciated. Review articles are highly appreciated. All articles published by Veterinary World are made freely and permanently accessible online. All articles to Veterinary World are posted online immediately as they are ready for publication.
期刊最新文献
Myristica fragrans Houtt. methanol extract as a promising treatment for Cryptosporidium parvum infection in experimentally immunosuppressed and immunocompetent mice. Assessment of health impacts in retired antisera-producing horses: Blood biochemistry and serum amyloid A analysis. Characterizing the bacteriophage PKp-V1 as a potential treatment for ESBL-producing hypervirulent K1 Klebsiella pneumoniae ST258 isolated from veterinary specimens. Cholangiocarcinoma: Consistent clinical, cytological, hematological, and biochemical findings and pathomorphology of the liver and kidney in five exotic dog breeds in Abeokuta, Nigeria. Comparative biochemical analysis of platelet-rich plasma-chitosan and platelet-rich fibrin-chitosan for treating tibial bone defects in rabbits.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1