The Effect of Rosuvastatin on Facial Nerve Regeneration After Facial Nerve Injury: An Experimental Animal Study.

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY Annals of Otology Rhinology and Laryngology Pub Date : 2024-11-06 DOI:10.1177/00034894241291814

Uğur Dincer, Ayşegül Verim, Çağrı Becerik, Nilüfer Gürsan, Çiğdem Tepe Karaca, Sema Zer Toros

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Abstract

Objectives: Rosuvastatin is an antihyperlipidemic statin group pharmacological agent with antioxidant, neuroprotective, and anti-inflammatory effects. In this study, we aimed to examine the functional, electrophysiological, and histopathological effects of rosuvastatin or in combination with corticosteroids on facial nerve regeneration in rats with traumatic peripheral facial paralysis (PFP).

Methods: PFP was induced in 28 female Sprague Dawley rats that we divided into 4 groups: group 1, control group; group 2, methylprednisolone group; group 3, rosuvastatin group; group 4, rosuvastatin and methylprednisolone group. Electrophysiological, functional, and histopathological examinations were performed before and after the medications.

Results: Electrophysiological threshold values of group 3 and group 4 were found to be significantly lower than the control group on day 21 after treatment (P = .002, P = .001; P < .01).In the histopathological evaluation, axonal degeneration, macrovacuolization, and vascular congestion levels were compared between the groups, and a statistically significant difference was observed in group 4 compared to the control group. The recovery time of the eye corneal reflex was found to be significantly higher in the control group than in groups 3 and 4 when comparing postoperative day 1 to day 7 and postoperative day 1 to day 14.

Conclusion: Rosuvastatin, especially when combined with methylprednisolone was found to significantly increase the facial nerve electrophysiological, functional, and histopathological recovery in injury-induced traumatic PFP.

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瑞舒伐他汀对面神经损伤后面神经再生的影响：一项动物实验研究

研究目的罗伐他汀是一种抗高血脂的他汀类药物，具有抗氧化、神经保护和抗炎作用。本研究旨在探讨洛伐他汀或与皮质类固醇合用对外伤性周围性面瘫（PFP）大鼠面神经再生的功能、电生理学和组织病理学影响：将28只雌性Sprague Dawley大鼠分为4组：第1组，对照组；第2组，甲基强的松龙组；第3组，洛伐他汀组；第4组，洛伐他汀和甲基强的松龙组。用药前后均进行了电生理、功能和组织病理学检查：结果：治疗后第 21 天，发现第 3 组和第 4 组的电生理阈值明显低于对照组（P = .002，P = .001；P 结论：罗舒伐他汀，尤其是联合使用罗舒伐他汀和甲泼尼龙时，可显著降低电生理阈值：发现瑞舒伐他汀，尤其是与甲基强的松龙联合使用时，可显著提高创伤性 PFP 患者的面神经电生理、功能和组织病理学恢复。

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来源期刊

Annals of Otology Rhinology and Laryngology 医学-耳鼻喉科学

CiteScore

3.10

自引率

7.10%

发文量

171

审稿时长

4-8 weeks

期刊介绍： The Annals of Otology, Rhinology & Laryngology publishes original manuscripts of clinical and research importance in otolaryngology–head and neck medicine and surgery, otology, neurotology, bronchoesophagology, laryngology, rhinology, head and neck oncology and surgery, plastic and reconstructive surgery, pediatric otolaryngology, audiology, and speech pathology. In-depth studies (supplements), papers of historical interest, and reviews of computer software and applications in otolaryngology are also published, as well as imaging, pathology, and clinicopathology studies, book reviews, and letters to the editor. AOR is the official journal of the American Broncho-Esophagological Association.