Engineering immune organoids to regenerate host immune system

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-11-06 DOI:10.1016/j.gde.2024.102276
Sefali Patel , Wen Liu , Ravikumar K , Catherine McCormick , Yong Fan
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Abstract

Recent advances in immunotherapy have underscored the potential of harnessing the immune system to treat disorders associated with immune dysregulation, such as primary and secondary immunodeficiencies, cancer, transplantation rejection, and aging. Owing to the cellular and structural complexity and the dynamic nature of immune responses, engineering immune organoids that replicate the function and key features of their corresponding immune organs continues to be a formidable challenge. In this overview, we will discuss the recent progress in bioengineering organoids of key primary and secondary immune organs and tissues, focusing particularly on their contributions to the host’s immune system in animal models and highlighting their potential roles in regenerative medicine.
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用免疫器官组织工程再生宿主免疫系统
免疫疗法的最新进展凸显了利用免疫系统治疗与免疫失调有关的疾病(如原发性和继发性免疫缺陷、癌症、移植排斥和衰老)的潜力。由于细胞和结构的复杂性以及免疫反应的动态性,工程化免疫类器官以复制其相应免疫器官的功能和关键特征仍然是一项艰巨的挑战。在这篇综述中,我们将讨论关键的一级和二级免疫器官和组织的生物工程类器官的最新进展,尤其关注它们在动物模型中对宿主免疫系统的贡献,并强调它们在再生医学中的潜在作用。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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