A small molecule that reshapes the chromatin dynamics of FOXA1

IF 14.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Cell Pub Date : 2024-11-07 DOI:10.1016/j.molcel.2024.10.019
Khadija Shahed Khan, Billy Wai-Lung Ng
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引用次数: 0

Abstract

In this issue, Won et al.1 report a covalent ligand binding the pioneer transcription factor FOXA1, altering its function and remodeling chromatin. This important finding highlights the potential of small molecules to modulate transcription factor activity and demonstrates the promise of chemical proteomics in discovering first-in-class ligands.
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重塑 FOXA1 染色质动力学的小分子
在本期杂志中,Won 等人1 报告了一种共价配体能与先锋转录因子 FOXA1 结合,改变其功能并重塑染色质。这一重要发现凸显了小分子调节转录因子活性的潜力,并证明了化学蛋白质组学在发现一流配体方面的前景。
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来源期刊
Molecular Cell
Molecular Cell 生物-生化与分子生物学
CiteScore
26.00
自引率
3.80%
发文量
389
审稿时长
1 months
期刊介绍: Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.
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