Discretised microfluidics for noninvasive health monitoring using sweat sensing

IF 6.1 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS Lab on a Chip Pub Date : 2024-11-06 DOI:10.1039/d4lc00763h
Emma J.M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap den Toonder
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Abstract

Monitoring of chemical biomarker concentrations is often necessary in modern healthcare facilities, but it remains a challenge to do this frequently, minimally invasively to the patient, and fit to workflows of healthcare professionals. The use of sweat as a biofluid can address these issues. Unlike blood, sweat can be noninvasively and continuously sampled without direct involvement of a professional, and sweat contains a rich composition of biomarkers. However, patients in resting state have extremely low sweat rates and they produce correspondingly small sweat volumes, which makes sweat sensing of hospitalised patients highly challenging. We propose a unique solution that enables the use of sweat as a viable biofluid for noninvasive health monitoring, by actively transporting the sweat in a discretised manner. Our device uses electrowetting-on-dielectrics (EWOD) to create and move sweat droplets with a volume of around 1 nanolitre from a sweat gland to sensors integrated in the device. We present the first wearable device with integrated EWOD, and we show that it can collect and transport sweat on-body, while measuring sweat rate.
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利用汗液感应进行无创健康监测的离散化微流体技术
在现代医疗机构中,经常需要对化学生物标志物的浓度进行监测,但如何频繁地进行监测、对病人的伤害最小并与医疗专业人员的工作流程相适应,仍然是一项挑战。使用汗液作为生物流体可以解决这些问题。与血液不同,汗液可以无创连续采样,无需专业人员直接参与,而且汗液中含有丰富的生物标志物。然而,病人在静息状态下的出汗率极低,出汗量也相应较小,这使得对住院病人进行汗液检测极具挑战性。我们提出了一种独特的解决方案,通过以离散方式主动传输汗液,将汗液作为一种可行的生物流体用于无创健康监测。我们的设备利用电介质电润湿(EWOD)技术产生体积约为 1 纳升的汗滴,并将其从汗腺输送到集成在设备中的传感器。我们展示了首款集成 EWOD 的可穿戴设备,并证明该设备可以收集和传输人体汗液,同时测量出汗率。
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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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Back cover Observing root growth and signalling responses to stress gradients and pathogens using the bi-directional dual-flow RootChip Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel† Microstring-engineered tension tissues: A novel platform for replicating tissue mechanics and advancing mechanobiology Discretised microfluidics for noninvasive health monitoring using sweat sensing
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