Efficiency and Diversity in Chemical Synthesis: Exploring One-Pot Multicomponent Reactions

IF 0.8 4区 化学 Q4 CHEMISTRY, ORGANIC Russian Journal of Organic Chemistry Pub Date : 2024-11-07 DOI:10.1134/S1070428024090185
P. Patel, H. Vaghani, J. Kumbhani, H. Kardani, S. Patel, Sh. Patel
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Abstract

This paper presents a broad overview of our research, which aims to develop new and effective synthetic approaches to structurally diverse heterocyclic scaffolds. Using multicomponent reactions (MCR), a wide variety of analogues from various families of heterocyclic compounds with many medicinal uses have been synthesized. Due to their affordability, eco-friendliness, and systematic synthesis in terms of reaction time, number of steps, yield, workup procedure, atom economy, and mild conditions, multicomponent reactions (MCRs) play a crucial role in achieving a greener approach in synthetic chemistry. MCRs offer a productive synthetic approach for a range of extremely complex compounds when paired with the one-pot process. The synthesis of highly functionalized molecules in a single pot to quickly generate libraries of biologically interesting compounds and find fresh leads as possible therapeutic agents is one of the distinctive features of MCRs. The current study covers the latest advancements and innovations of MCRs in the entire synthesis of nitrogen-, sulfur-, and oxygen-containing heterocyclic compounds.

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化学合成的效率和多样性:探索单锅多组分反应
本文概括介绍了我们的研究,该研究旨在为结构多样的杂环支架开发新的有效合成方法。利用多组分反应(MCR),我们合成了多种具有多种药用价值的杂环化合物家族的类似物。由于多组分反应(MCR)在反应时间、步骤数量、产率、操作步骤、原子经济性和温和条件等方面具有经济实惠、生态友好和系统合成的特点,因此在实现更环保的合成化学方法方面发挥着至关重要的作用。多组分反应与单锅工艺相结合,可为一系列极其复杂的化合物提供富有成效的合成方法。一锅合成高官能度分子,快速生成具有生物学意义的化合物库,找到新的治疗药物线索,是 MCR 的显著特点之一。本研究涵盖了 MCR 在含氮、硫和氧杂环化合物整个合成过程中的最新进展和创新。
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来源期刊
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍: Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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