Synthesis of a Misoprostol Analogue, 11-Deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B1 Ethyl Ester

IF 0.8 4区 化学 Q4 CHEMISTRY, ORGANIC Russian Journal of Organic Chemistry Pub Date : 2024-11-07 DOI:10.1134/S1070428024090094
N. A. Ivanova, G. A. Shavaleeva, L. V. Spirikhin, M. S. Miftakhov
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Abstract

1,2-Addition of lithiated 4-hydroxy-4,5-dimethylhept-1-yne to the keto group of ethyl 7-(5-oxocyclopent-1-en-1-yl)heptanoate, followed by in situ oxidative isomerization of the adduct afforded 11-deoxy-13,14-didehydro-17-methyl-20-norprostaglandin B1 (PGB1) ethyl ester.

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米索前列醇类似物 11-脱氧-13,14-二脱氢-17-甲基-20-去甲前列腺素 B1 乙酯的合成
1,2-将石炭酸化的 4-羟基-4,5-二甲基庚-1-炔添加到 7-(5-氧代环戊-1-烯-1-基)庚酸乙酯的酮基上,然后对加合物进行原位氧化异构化,得到 11-脱氧-13,14-二脱氢-17-甲基-20-去甲前列腺素 B1 (PGB1) 乙酯。
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来源期刊
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍: Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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