Synthesis and Antihypoxic Properties of New 2-(1,4-Benzodioxan-2-yl)-1,3,4-oxadiazole Derivatives

IF 0.8 4区 化学 Q4 CHEMISTRY, ORGANIC Russian Journal of Organic Chemistry Pub Date : 2024-11-07 DOI:10.1134/S1070428024090100
S. O. Vardanyan, A. S. Avagyan, A. B. Sargsyan, H. A. Panosyan, S. A. Harutyunyan, H. V. Gasparyan, A. A. Aghekyan
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Abstract

The condensation of previously described 1,4-benzodioxane-2-carbohydrazide with various 1-(sub­stituted phenyl)cycloalkan-1-carbonyl chlorides, as well as 4-aryltetrahydropyran-4-carbonyl chloride gave N,N′-diacylhydrazines which were cyclized by the action of phosphoryl chloride to the corresponding 2-(1,4-benzodioxan-2-yl)-1,3,4-oxadiazole derivatives. The synthesized compounds were evaluated for anti­hypoxic activity.

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新型 2-(1,4-苯并二恶烷-2-基)-1,3,4-恶二唑衍生物的合成与抗缺氧特性
以前描述的 1,4-苯并二恶烷-2-甲酰肼与各种 1-(取代苯基)环烷烃-1-甲酰氯以及 4-芳基四氢吡喃-4-甲酰氯缩合,得到 N,N′-二酰肼,在磷酰氯的作用下环化成相应的 2-(1,4-苯并二恶烷-2-基)-1,3,4-噁二唑衍生物。对合成的化合物进行了抗缺氧活性评估。
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来源期刊
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍: Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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