Anti-aging potential of Cephalotaxus harringtonia extracts: the role of harringtonine and homoharringtonine in skin protection

IF 2.3 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Applied Biological Chemistry Pub Date : 2024-11-08 DOI:10.1186/s13765-024-00951-1
Si-Young Ahn, Chang-Dae Lee, Ja Jung Ku, Sanghyun Lee, Sullim Lee
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Abstract

Photoaging damages the skin layers. The tumor necrosis factor-alpha (TNF-α) plays a crucial role in the central mechanism of photoaging. TNF-α production leads to direct damage to skin cells and facilitates the degradation of vital extracellular matrix (ECM) proteins. TNF-α stimulates matrix metalloproteinase-1 (MMP-1) activation This accelerates the loss of skin elasticity and wrinkle formation. Thus, preventing photoaging and delaying the skin aging process are important research objectives, and the development of new anti-aging substances that target the TNF-α and MMP-1 pathways is promising. In this context, the efficacies of four extracts derived from two types of Cephalotaxus harringtonia (CH) buds (CH-10Y-buds, CH-200Y-buds) and leaves (CH-10Y-leaves, CH-200Y-leaves) were investigated, exhibiting a significant reduction in reactive oxygen species (ROS). Among the four extracts, CH-10Y-buds was the most effective in reducing ROS and exhibited the highest amounts of harringtonine and homoharringtonine. The activities of harringtonine, homoharringtonine, and ginkgetin were evaluated; harringtonine exhibited a high efficacy in inhibiting TNF-α-induced inflammatory responses and MMP-1 activation, thereby reducing collagen degradation. These findings suggest that CH-10Y-buds and their components herringtonin are promising candidates for preventing damage caused by photoaging. Our results can facilitate the development of new methods for maintaining skin health and inhibiting the skin aging process. Further research is necessary to comprehensively evaluate the potential efficacy of these candidate substances and investigate their applicability to actual skin. Such studies will aid in the development of more effective anti-aging strategies in the future.

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鱼腥草提取物的抗衰老潜力:鱼腥草碱和同鱼腥草碱在皮肤保护中的作用
光老化会损伤皮肤层。肿瘤坏死因子-α(TNF-α)在光老化的核心机制中起着至关重要的作用。TNF-α 的产生会直接损伤皮肤细胞,并促进重要细胞外基质(ECM)蛋白质的降解。TNF-α 会刺激基质金属蛋白酶-1(MMP-1)的活化,从而加速皮肤弹性的丧失和皱纹的形成。因此,防止光老化和延缓皮肤老化过程是重要的研究目标,而开发针对 TNF-α 和 MMP-1 通路的新型抗衰老物质则大有可为。在此背景下,研究人员对从两种类型的头状花序(CH)芽(CH-10Y-芽、CH-200Y-芽)和叶(CH-10Y-叶、CH-200Y-叶)中提取的四种提取物的功效进行了调查,结果表明这四种提取物能显著减少活性氧(ROS)。在四种萃取物中,CH-10Y-芽降低 ROS 的效果最好,所含的哈灵碱和高哈灵碱也最高。对哈灵单宁、高哈灵单宁和银杏黄酮的活性进行了评估;哈灵单宁在抑制 TNF-α 诱导的炎症反应和 MMP-1 活化方面表现出很高的功效,从而减少了胶原蛋白的降解。这些研究结果表明,CH-10Y-buds 及其成分herringtonin 有希望成为预防光老化损伤的候选物质。我们的研究结果有助于开发维护皮肤健康和抑制皮肤老化过程的新方法。要全面评估这些候选物质的潜在功效并研究它们对实际皮肤的适用性,还需要进一步的研究。这些研究将有助于未来开发更有效的抗衰老策略。
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来源期刊
Applied Biological Chemistry
Applied Biological Chemistry Chemistry-Organic Chemistry
CiteScore
5.40
自引率
6.20%
发文量
70
审稿时长
20 weeks
期刊介绍: Applied Biological Chemistry aims to promote the interchange and dissemination of scientific data among researchers in the field of agricultural and biological chemistry. The journal covers biochemistry and molecular biology, medical and biomaterial science, food science, and environmental science as applied to multidisciplinary agriculture.
期刊最新文献
Anti-aging potential of Cephalotaxus harringtonia extracts: the role of harringtonine and homoharringtonine in skin protection Publisher Correction to: Development of Bacillus stratosphericus Lysate Concentrate to Control Sebum Secretion through In vitro Studies and Clinical Trial In vitro effectiveness of CB469, a MET tyrosine kinase inhibitor in MET-activated cancer cells Correction: Characterization of acidogenic phase metabolism in Clostridium acetobutylicum ATCC 824 (pCD07239) under different culture conditions Preparation of α-zein loaded with baicalincomposites: A study on their in vitro simulated digestive behavior and molecular dynamics simulation
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