Hyuga Okumura, Nurcahyo Iman Prakoso, Tatsuya Morozumi, Taiki Umezawa
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引用次数: 0
Abstract
The reductive conversion of vicinal and geminal dibromoalkenes into the corresponding alkynes with iPrMgCl-LiCl (Turbo Grignard reagent) is described. This reaction proceeded in the presence of various functional groups such as ethers, esters, or carbamates under mild conditions in high yields. Due to the selective reactivity, the easily prepared vic-dibromoalkene is considered to be a protecting group of alkyne toward an electrophile. Although butyl lithium has been widely used for the conversion of gem-dibromoalkenes into alkynes in the Corey–Fuchs alkyne synthesis, we report here alternative mild and chemoselective reaction conditions for alkyne synthesis.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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