Biological functions and pharmacological behaviors of bile acids in metabolic diseases

IF 11.4 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Journal of Advanced Research Pub Date : 2024-11-08 DOI:10.1016/j.jare.2024.11.003
Tongxi Zhuang, Xunjiang Wang, Zixuan Wang, Lihua Gu, Dawei Yue, Zhengtao Wang, Xiaohua Li, Li Yang, Wendong Huang, Lili Ding
{"title":"Biological functions and pharmacological behaviors of bile acids in metabolic diseases","authors":"Tongxi Zhuang, Xunjiang Wang, Zixuan Wang, Lihua Gu, Dawei Yue, Zhengtao Wang, Xiaohua Li, Li Yang, Wendong Huang, Lili Ding","doi":"10.1016/j.jare.2024.11.003","DOIUrl":null,"url":null,"abstract":"<h3>Background</h3>Bile acids (BAs), synthesized endogenously from cholesterol, play a central role in metabolic regulation within the enterohepatic circulatory system. Traditionally known as emulsifying agents that facilitate the intestinal absorption of vitamins and lipids, recent research reveals their function as multifaceted signal modulators involved in various physiological processes. These molecules are now recognized as key regulators of chronic metabolic diseases and immune dysfunction. Despite progress in understanding their roles, their structural diversity and the specific functions of individual bile acids remain underexplored.<h3>Aim of review</h3>This study categorizes the bile acids based on their chemical structures and their roles as signaling molecules in physiological processes. It consolidates current knowledge and provides a comprehensive overview of the current research. The review also includes natural and semisynthetic variants that have demonstrated potential in regulating metabolic processes in animal models or clinical contexts.<h3>Key scientific concepts of review</h3>Bile acids circulate primarily within the enterohepatic circulation, where they help maintain a healthy digestive system. Disruptions in their balance are linked to metabolic disorders, hepatobiliary diseases and intestinal inflammation. Through receptor-mediated pathways, bile acids influence the progression of metabolic diseases by regulating glucose and lipid metabolism, immune function, and energy expenditure. This review aims to provide a comprehensive, systematic foundation to for understanding their physiological roles and supporting future therapeutic developments for metabolic and inflammatory diseases.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":null,"pages":null},"PeriodicalIF":11.4000,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Advanced Research","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1016/j.jare.2024.11.003","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Background

Bile acids (BAs), synthesized endogenously from cholesterol, play a central role in metabolic regulation within the enterohepatic circulatory system. Traditionally known as emulsifying agents that facilitate the intestinal absorption of vitamins and lipids, recent research reveals their function as multifaceted signal modulators involved in various physiological processes. These molecules are now recognized as key regulators of chronic metabolic diseases and immune dysfunction. Despite progress in understanding their roles, their structural diversity and the specific functions of individual bile acids remain underexplored.

Aim of review

This study categorizes the bile acids based on their chemical structures and their roles as signaling molecules in physiological processes. It consolidates current knowledge and provides a comprehensive overview of the current research. The review also includes natural and semisynthetic variants that have demonstrated potential in regulating metabolic processes in animal models or clinical contexts.

Key scientific concepts of review

Bile acids circulate primarily within the enterohepatic circulation, where they help maintain a healthy digestive system. Disruptions in their balance are linked to metabolic disorders, hepatobiliary diseases and intestinal inflammation. Through receptor-mediated pathways, bile acids influence the progression of metabolic diseases by regulating glucose and lipid metabolism, immune function, and energy expenditure. This review aims to provide a comprehensive, systematic foundation to for understanding their physiological roles and supporting future therapeutic developments for metabolic and inflammatory diseases.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
胆汁酸在代谢性疾病中的生物功能和药理作用
背景胆汁酸(BA)由胆固醇内源合成,在肠肝循环系统的代谢调节中发挥着核心作用。传统上,胆汁酸被认为是促进肠道吸收维生素和脂质的乳化剂,最近的研究揭示了胆汁酸作为参与各种生理过程的多方面信号调节剂的功能。这些分子现在被认为是慢性代谢疾病和免疫功能障碍的关键调节因子。本研究根据胆汁酸的化学结构及其在生理过程中作为信号分子的作用对胆汁酸进行了分类。它整合了当前的知识,并对当前的研究进行了全面概述。综述还包括在动物模型或临床环境中显示出调节代谢过程潜力的天然和半合成变体。胆汁酸平衡的破坏与代谢紊乱、肝胆疾病和肠道炎症有关。胆汁酸通过受体介导的途径,调节葡萄糖和脂质代谢、免疫功能和能量消耗,从而影响代谢性疾病的进展。本综述旨在为了解胆汁酸的生理作用和支持未来代谢性和炎症性疾病的治疗发展提供全面、系统的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Journal of Advanced Research
Journal of Advanced Research Multidisciplinary-Multidisciplinary
CiteScore
21.60
自引率
0.90%
发文量
280
审稿时长
12 weeks
期刊介绍: Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.
期刊最新文献
Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic review Host genetic regulation of specific functional groups in the rumen microbiome of dairy cows: Implications for lactation trait Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms Biological functions and pharmacological behaviors of bile acids in metabolic diseases
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1