Resveratrol nanoparticles coated by metal-polyphenols supramolecular enhance antioxidant activity and long-term stability of dietary gel

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2024-11-09 DOI:10.1016/j.foodchem.2024.141987

Yiyang Chai, Ying Zhou, Kai Zhang, Ping Shao

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Abstract

Resveratrol (RES) is an important functional substance with multiple active properties. However, RES is susceptible to natural environmental conditions that reduce its bioactivity. To improve the bioavailability of RES, in this study, Catechin and Fe³⁺/Ca²⁺ were selected to form supramolecules, which were then coated on the surface of hydrophobic RES nanoparticles (RES NPs) to create composite RES NPs. The obtained composite RES NPs demonstrated higher antioxidant capacity and better photo-thermal stability than RES NPs. Additionally, a pectin (PE) dietary gel was designed as a delivery carrier for RES. The results showed that the incorporation of composite RES NPs not only endowed the gels with significant dietary activity but also enhanced the texture, water retention capacity and hydrophobicity. After 28 days of storage, the retention rate of RES could be maintained above 90 % in the dietary gels. Meanwhile, the controlled release of RES was achieved in in vitro simulated digestion.

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金属多酚超分子包覆的白藜芦醇纳米颗粒可增强膳食凝胶的抗氧化活性和长期稳定性

白藜芦醇（RES）是一种重要的功能性物质，具有多种活性特性。然而，白藜芦醇易受自然环境条件的影响而降低其生物活性。为了提高 RES 的生物利用率，本研究选择儿茶素和 Fe3+/Ca2+ 形成超分子，然后将其包覆在疏水性 RES 纳米颗粒（RES NPs）表面，形成复合 RES NPs。与 RES NPs 相比，所获得的复合 RES NPs 具有更高的抗氧化能力和更好的光热稳定性。此外，还设计了一种果胶（PE）膳食凝胶作为RES的输送载体。结果表明，复合 RES NPs 的加入不仅赋予了凝胶显著的膳食活性，还增强了凝胶的质地、保水能力和疏水性。贮存 28 天后，RES 在膳食凝胶中的保留率可保持在 90% 以上。同时，在体外模拟消化中实现了 RES 的控制释放。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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