Plant pattern recognition receptors: from evolutionary insight to engineering

IF 39.1 1区 生物学 Q1 GENETICS & HEREDITY Nature Reviews Genetics Pub Date : 2024-11-11 DOI:10.1038/s41576-024-00793-z
Simon Snoeck, Oliver Johanndrees, Thorsten Nürnberger, Cyril Zipfel
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Abstract

The plant immune system relies on germline-encoded pattern recognition receptors (PRRs) that sense foreign and plant-derived molecular patterns, and signal health threats. Genomic and pangenomic data sets provide valuable insights into the evolution of PRRs and their molecular triggers, which is furthering our understanding of plant–pathogen co-evolution and convergent evolution. Moreover, in silico and in vivo methods of PRR identification have accelerated the characterization of receptor–ligand complexes, and advances in protein structure prediction algorithms are revealing novel PRR sensor functions. Harnessing these recent advances to engineer PRRs presents an opportunity to enhance plant disease resistance against a broad spectrum of pathogens, enabling more sustainable agricultural practices. This Review summarizes both established and innovative approaches to leverage genomic data and translate resulting evolutionary insights into engineering PRR recognition specificities.

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植物模式识别受体:从进化论到工程学
植物免疫系统依靠种系编码的模式识别受体(PRRs)来感知外来和植物衍生的分子模式,并发出健康威胁信号。基因组和泛基因组数据集为 PRRs 及其分子触发器的进化提供了宝贵的见解,从而进一步加深了我们对植物-病原体共同进化和趋同进化的理解。此外,PRR 的硅学和体内鉴定方法加快了受体-配体复合物的表征,蛋白质结构预测算法的进步揭示了新的 PRR 传感器功能。利用这些最新进展对 PRRs 进行工程设计,为提高植物对各种病原体的抗病性提供了机会,从而实现更可持续的农业实践。本综述总结了利用基因组数据并将由此产生的进化见解转化为工程化 PRR 识别特异性的既有方法和创新方法。
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来源期刊
Nature Reviews Genetics
Nature Reviews Genetics 生物-遗传学
CiteScore
57.40
自引率
0.50%
发文量
113
审稿时长
6-12 weeks
期刊介绍: At Nature Reviews Genetics, our goal is to be the leading source of reviews and commentaries for the scientific communities we serve. We are dedicated to publishing authoritative articles that are easily accessible to our readers. We believe in enhancing our articles with clear and understandable figures, tables, and other display items. Our aim is to provide an unparalleled service to authors, referees, and readers, and we are committed to maximizing the usefulness and impact of each article we publish. Within our journal, we publish a range of content including Research Highlights, Comments, Reviews, and Perspectives that are relevant to geneticists and genomicists. With our broad scope, we ensure that the articles we publish reach the widest possible audience. As part of the Nature Reviews portfolio of journals, we strive to uphold the high standards and reputation associated with this esteemed collection of publications.
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