A method to detect origin of transfer sequences for plasmid conjugation

IF 3.5 3区医学 Q2 CHEMISTRY, MEDICINAL ACS Medicinal Chemistry Letters Pub Date : 2024-11-13 DOI:10.1038/s41564-024-01845-0

引用次数: 0

Abstract

Plasmid conjugation has been extensively studied over the past decades. Yet, in most plasmids, the minimal region required for conjugation (the origin of transfer (oriT) sequence) is unknown. The characterization of known oriTs enabled the development of a validated method to identify genomic regions with novel families of oriTs across bacterial plasmids.

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一种检测质粒共轭转移序列起源的方法

过去几十年来，人们对质粒共轭进行了广泛的研究。然而，在大多数质粒中，共轭所需的最小区域（转运起源（oriT）序列）是未知的。通过对已知 oriT 的特征描述，我们开发出了一种有效的方法来识别细菌质粒中具有新型 oriT 家族的基因组区域。

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来源期刊

ACS Medicinal Chemistry Letters CHEMISTRY, MEDICINAL-

CiteScore

7.30

自引率

2.40%

发文量

328

审稿时长

1 months

期刊介绍： ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to: Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics) Biological characterization of new molecular entities in the context of drug discovery Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc. Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry Discovery technologies for biologically active molecules from both synthetic and natural (plant and other) sources Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic Mechanistic drug metabolism and regulation of metabolic enzyme gene expression Chemistry patents relevant to the medicinal chemistry field.

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