{"title":"Palladium-catalyzed difluoroalkylative carbonylation of unactivated alkenes toward γ-Lactams","authors":"Xin Qi , Yuanrui Wang , Xiao-Feng Wu","doi":"10.1016/j.jcat.2024.115839","DOIUrl":null,"url":null,"abstract":"<div><div>γ-Lactams are important core structure found in various natural and biologically active compounds. And the introducing of difluoromethylene group into a molecule can change its physical, chemical, and biological properties. As carbonylation chemistry represent a powerful and efficient method for the synthesis of carbonylated compounds, we report here an efficient procedure for the construction of difluoroalkylative γ-lactams via palladium-catalyzed carbonylative cyclization of alkenes. The desired γ-lactams were produced in moderate to good yields under relatively mild conditions.</div></div>","PeriodicalId":346,"journal":{"name":"Journal of Catalysis","volume":"440 ","pages":"Article 115839"},"PeriodicalIF":6.5000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Catalysis","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0021951724005529","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
γ-Lactams are important core structure found in various natural and biologically active compounds. And the introducing of difluoromethylene group into a molecule can change its physical, chemical, and biological properties. As carbonylation chemistry represent a powerful and efficient method for the synthesis of carbonylated compounds, we report here an efficient procedure for the construction of difluoroalkylative γ-lactams via palladium-catalyzed carbonylative cyclization of alkenes. The desired γ-lactams were produced in moderate to good yields under relatively mild conditions.
期刊介绍：
The Journal of Catalysis publishes scholarly articles on both heterogeneous and homogeneous catalysis, covering a wide range of chemical transformations. These include various types of catalysis, such as those mediated by photons, plasmons, and electrons. The focus of the studies is to understand the relationship between catalytic function and the underlying chemical properties of surfaces and metal complexes.
The articles in the journal offer innovative concepts and explore the synthesis and kinetics of inorganic solids and homogeneous complexes. Furthermore, they discuss spectroscopic techniques for characterizing catalysts, investigate the interaction of probes and reacting species with catalysts, and employ theoretical methods.
The research presented in the journal should have direct relevance to the field of catalytic processes, addressing either fundamental aspects or applications of catalysis.
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