Effect of hepatitis B virus infection on the nutrient composition of human breast milk: A prospective cohort study

IF 9.8 1区 农林科学 Q1 CHEMISTRY, APPLIED Food Chemistry Pub Date : 2025-02-15 Epub Date: 2024-11-13 DOI:10.1016/j.foodchem.2024.141947
Peizhen Zhang , Huiqi Jian , Chuo Li , Lin Yao , Tiantian He , Zhangmin Tan , Jin Zhou , Yuzhu Yin
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Abstract

There are limited data regarding the impact of Hepatitis B virus (HBV) infection on the composition of human breast milk, and there is no international consensus on the nutritional management of newborns of HBV-positive mothers. We hypothesised that HBV infection can alter the composition of breast milk and that newborns require additional nutritional supplements for healthy growth. We conducted a prospective observational cohort study that recruited 150 pregnant women with HBV infection and matched them with a healthy control group. Multivariate linear regression analysis revealed that glucose and albumin concentrations were increased in the HBV group (av. 4.65 mmol/L and av. 5.66 g/L, respectively), whereas lactoferrin concentrations decreased (av. 537.68 pg/mL). Therefore, additional lactoferrin supplementation may be necessary for newborns delivered to women with HBV infection.

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乙型肝炎病毒感染对母乳营养成分的影响:前瞻性队列研究
有关乙型肝炎病毒(HBV)感染对母乳成分影响的数据很有限,国际上也没有就 HBV 阳性母亲的新生儿营养管理达成共识。我们假设 HBV 感染会改变母乳的成分,新生儿需要额外的营养补充才能健康成长。我们开展了一项前瞻性观察性队列研究,招募了 150 名 HBV 感染孕妇,并将她们与健康对照组进行配对。多变量线性回归分析显示,HBV 组的葡萄糖和白蛋白浓度增加(平均值分别为 4.65 mmol/L 和 5.66 g/L),而乳铁蛋白浓度降低(平均值为 537.7 pg/ml)。因此,感染 HBV 的妇女所生的新生儿可能需要额外补充乳铁蛋白。
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来源期刊
Food Chemistry
Food Chemistry 工程技术-食品科技
CiteScore
16.30
自引率
10.20%
发文量
3130
审稿时长
122 days
期刊介绍: Food Chemistry publishes original research papers dealing with the advancement of the chemistry and biochemistry of foods or the analytical methods/ approach used. All papers should focus on the novelty of the research carried out.
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