Clinical characteristics and risk factors analysis of abdominal symptoms in IgA vasculitis patients: a retrospective cohort study.

Abstract

About 50% of children with IgA vasculitis (IgAV) have abdominal symptoms, usually colic mimic to acute abdomen. Since signs and symptoms of vasculitis may appear in any order, this may affect the diagnosis of children whose abdominal symptoms precede the appearance of purpura. It is necessary to identify the risk factors, pathogenesis, and specific biomarkers to improve the prevention and management of IgAV patients with abdominal symptoms. All the 278 patients were children who had been diagnosed with IgAV in Nanyang Central Hospital between January 2018 and December 2018. The patient's age, gender, clinical manifestations, laboratory examination, and medical history were retrospectively collected. All the patients were divided into two groups based on whether they had abdominal symptoms. Ridge regression and multivariate logistic regression model were used to find risk factors of IgAV patients with abdominal symptoms. Of the 278 patients, 54 patients had abdominal symptoms, and the remaining 224 patients had no abdominal symptoms. Patients with abdominal symptoms had a lower proportion of infections and higher IgM concentrations than patients with other symptoms. For patients over 12 years of age, platelet counts were lower in patients with abdominal symptoms. In addition, basophil count was identified as a protective factor, while IgM was identified as a risk factor. Infections, platelet counts, basophil count, and IgM concentration may be associated with abdominal symptoms in IgAV patients. Basophils and IgM may be involved in the pathological mechanism of abdominal symptoms.