Pretreatment Quality of Life and Substance Use Among Patients Diagnosed With Head and Neck Cancer

IF 2.9 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2024-11-08 DOI:10.1002/cam4.70399

Eric Adjei Boakye, Sami I. Nassar, Suma J. Alzouhayli, Amy M. Williams, Steven S. Chang, Tamer A. Ghanem, Marissa Gilbert, Suhael Momin, Farzan Siddiqui, Vivian F. Wu, Samantha H. Tam

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Abstract

Background

There is a paucity of research on the effects of commonly used substances, such as cannabis and other drugs, on quality of life as a contributor to head and neck cancer (HNC) prognosis. We examined associations between non-alcohol or tobacco substance use (cannabis and other illicit drug) and self-reported quality of life in patients with HNC prior to starting treatment.

Methods

This was a cross-sectional study of patients who presented for routine psych-oncologevaluation prior to treatment between 11/2015 and 9/2022. Primary exposures were cannabis use (never, past, or current users) and current illicit drug use (yes/no). The primary outcome measure was the Functional Assessment of Cancer Therapy—Head and Neck (FACT-HN) subscales (physical, social/family, functional and emotional). Linear regression models examined associations between pretreatment substance use and FACT-HN subscales adjusting for demographic, socioeconomic, and clinical factors.

Results

Of 570 patients, 13.9% endorsed current cannabis and 13.9% current illicit drug use. The mean (SD) scores for FACT-HN subscales were physical well-being = 22.8 (5.0), social well-being = 22.7 (5.5), emotional well-being = 17.5 (4.5), and functional well-being = 18.7 (6.9). In the adjusted models, cannabis use was not independently associated with any FACT-HN subscales. However, patients who currently used illicit drugs reported worse emotional well-being (β = −1.32; 95% CI −2.45 to −0.20). No independent association was found between current illicit drug use and other subscales (physical, social, and functional).

Conclusions

Illicit drug use, but not cannabis use, is negatively associated with pretreatment emotional well-being in patients with HNC. Further research exploring the relationships between longitudinal cannabis and illicit drug use and methods of consumption on QoL and cancer outcomes in patients with head and neck cancer is warranted.

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头颈癌患者治疗前的生活质量和药物使用情况。

背景：大麻和其他药物等常用药物对生活质量的影响是头颈癌（HNC）预后的一个因素，但有关这方面的研究却很少。我们研究了HNC患者在开始治疗前使用非酒精或烟草物质（大麻和其他非法药物）与自我报告的生活质量之间的关系：这是一项横断面研究，研究对象为2015年11月至2022年9月期间接受治疗前常规肿瘤心理评估的患者。主要暴露因素为大麻使用（从未使用、过去使用或现在使用）和当前非法药物使用（是/否）。主要结果测量是癌症治疗功能评估-头颈部（FACT-HN）分量表（身体、社交/家庭、功能和情感）。线性回归模型检验了治疗前药物使用与 FACT-HN 分量表之间的关系，并对人口、社会经济和临床因素进行了调整：在 570 名患者中，13.9% 表示目前使用大麻，13.9% 表示目前使用非法药物。FACT-HN 分量表的平均（标清）得分分别为身体健康 = 22.8 (5.0)、社交健康 = 22.7 (5.5)、情绪健康 = 17.5 (4.5) 和功能健康 = 18.7 (6.9)。在调整后的模型中，吸食大麻与 FACT-HN 的任何分量表均无独立关联。然而，目前使用非法药物的患者的情绪健康状况较差（β = -1.32; 95% CI -2.45至-0.20）。目前使用非法药物与其他分量表（身体、社交和功能）之间未发现独立关联：非法药物使用（而非大麻使用）与 HNC 患者治疗前的情绪健康呈负相关。有必要开展进一步研究，探讨头颈癌患者纵向大麻和非法药物使用及消费方式与 QoL 和癌症预后之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.