Changes in the estimated glucose disposal rate and incident cardiovascular disease: two large prospective cohorts in Europe and Asia.

IF 8.5 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Cardiovascular Diabetology Pub Date : 2024-11-07 DOI:10.1186/s12933-024-02485-8

Xiaowei Zheng, Wenyang Han, Yiqun Li, Minglan Jiang, Xiao Ren, Pinni Yang, Yiming Jia, Lulu Sun, Ruirui Wang, Mengyao Shi, Zhengbao Zhu, Yonghong Zhang

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Abstract

Background and aims: Previous study found that estimated glucose disposal rate (eGDR) was significantly associated with cardiovascular disease (CVD). However, little is known about the change in eGDR over time and its association with the development of CVD. The aim of this study was to investigate the association of change in eGDR with CVD risk.

Methods: This study used data of two prospective cohorts: UK Biobank and China Health and Retirement Longitudinal Study (CHARLS) with two measurements of eGDR. Changes in the eGDR were classified using K‑means clustering analysis, and the cumulative eGDR was also calculated. Cox proportional hazard models were used to calculate the hazard ratio (HR) and 95% confidence interval (95% CI) after adjusting for potential confounders.

Results: A total of 11,682 individuals from the UK Biobank, and 4,974 individuals from the CHARLS were included. The median follow-up periods were 9.7 years in the UK Biobank and 3.0 years in the CHARLS. Compared with persistently high level of eGDR (class 1), individuals with low level increasing (class 3) and persistently low level of eGDR (class 4) showed elevated risks of incident CVD in both UK Biobank (HR = 2.79, 95% 2.15-3.62 for class 3; HR = 3.19, 95% 2.50-4.08 for class 4) and CHARLS (HR = 1.66, 95% 1.29-2.13 for class 3; HR = 1.69, 95% 1.34-2.14 for class 4). In addition, lower level of cumulative eGDR were associated with elevated risks of incident CVD. The dose-response curve between cumulative eGDR and CVD risk showed a negative linear relationship.

Conclusion: Different changes in eGDR level are associated with different risks of incident CVD. Dynamic monitoring of eGDR level is of significant importance for the CVD prevention and treatment.

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估计葡萄糖处置率的变化与心血管疾病的发生：欧洲和亚洲的两个大型前瞻性队列。

背景和目的：先前的研究发现，估计葡萄糖排出率（eGDR）与心血管疾病（CVD）有显著相关性。然而，人们对 eGDR 随时间的变化及其与心血管疾病发展的关系知之甚少。本研究旨在探讨 eGDR 的变化与心血管疾病风险的关系：本研究使用了两个前瞻性队列的数据：方法：本研究使用了两个前瞻性队列的数据：英国生物库（UK Biobank）和中国健康与退休纵向研究（CHARLS），并对 eGDR 进行了两次测量。使用 K-means 聚类分析对 eGDR 的变化进行分类，并计算累计 eGDR。在调整潜在的混杂因素后，采用 Cox 比例危险模型计算危险比（HR）和 95% 置信区间（95% CI）：共纳入了英国生物库中的 11,682 人和 CHARLS 中的 4,974 人。英国生物库的随访时间中位数为 9.7 年，CHARLS 的随访时间中位数为 3.0 年。在英国生物库（HR = 2.79，95% 2.15-3.62（3 级）；HR = 3.19，95% 2.50-4.08（4 级））和 CHARLS（HR = 1.66，95% 1.29-2.13（3 级）；HR = 1.69，95% 1.34-2.14（4 级））中，与持续高水平 eGDR（1 级）相比，低水平 eGDR 增加（3 级）和持续低水平 eGDR（4 级）的个体发生心血管疾病的风险较高。此外，累积 eGDR 水平较低与心血管疾病发生风险升高有关。累积 eGDR 与心血管疾病风险之间的剂量-反应曲线呈负线性关系：结论：eGDR水平的不同变化与心血管疾病发病风险的不同有关。动态监测 eGDR 水平对心血管疾病的预防和治疗具有重要意义。

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来源期刊

Cardiovascular Diabetology 医学-内分泌学与代谢

CiteScore

12.30

自引率

15.10%

发文量

240

审稿时长

1 months

期刊介绍： Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.