Bone Status in Patients with Monoclonal Gammopathy of Undetermined Significance: A Case-Control Study.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Annals of African Medicine Pub Date : 2024-11-08 DOI:10.4103/aam.aam_34_24

Laila Taoubane, Salim Jennane, Hajar El Hani, Abedarhim Majjad, Hamza Toufik, Najlae El Ouardi, Kamal Doghmi, Lahsen Achemlal, Abdellah El Maghraoui, Ahmed Bezza

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Abstract

Objective: The objective of the study was to assess the prevalence of osteoporosis in patients with monoclonal gammopathy of undetermined significance (MGUS) and to determine the associated factors.

Materials and methods: We conducted a case-control study, between January 2019 and April 2019, including patients with MGUS and age- and sex-matched healthy controls (one patient/three controls). For all participants, demographic and clinical data were collected as results of bone mineral density by two-photon X-ray absorptiometry at the lumbar spine and femoral neck.

Results: In our series, we included 120 participants: 30 patients with MGUS and 90 healthy controls. In the MGUS carrier group, the mean age was 66.26 ± 8.61 years. The mean monoclonal peak was 11.57 g/L. Densitometric osteoporosis was noted in 12 (40%) patients with MGUS versus 17 (18.9%) in the control group (P = 0.021). In addition, only one patient with MGUS had a vertebral fracture. On multivariate analysis, associated factors with osteoporosis in the MGUS group were age (odds ratio [OR] = 1.14; confidence interval [CI] [1.03-1.26]; P < 0.05) and previous fracture (OR = 3.03; CI [1.22-15.06]; P < 0.05).

Conclusion: Our study suggests an increased risk of osteoporosis in patients with MGUS.

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意义未定的单克隆丙种球蛋白病患者的骨骼状况：病例对照研究

研究目的本研究旨在评估意义未定的单克隆性淋巴瘤病（MGUS）患者骨质疏松症的患病率，并确定相关因素：我们在2019年1月至2019年4月期间开展了一项病例对照研究，研究对象包括MGUS患者以及年龄和性别匹配的健康对照组（1名患者/3名对照组）。我们收集了所有参与者的人口统计学和临床数据，以及腰椎和股骨颈处双光子X射线吸收测量法得出的骨矿密度结果：在我们的系列研究中，共纳入了 120 名参与者：结果：在我们的系列研究中，共纳入了120名参与者：30名MGUS患者和90名健康对照者。MGUS携带者组的平均年龄为（66.26 ± 8.61）岁。平均单克隆峰值为 11.57 克/升。12 例（40%）MGUS 患者出现骨密度测量骨质疏松症，而对照组为 17 例（18.9%）（P = 0.021）。此外，只有一名 MGUS 患者发生了脊椎骨折。多变量分析显示，MGUS 组骨质疏松症的相关因素为年龄（比值比 [OR] = 1.14；置信区间 [CI] [1.03-1.26]；P <0.05）和既往骨折（OR = 3.03；CI [1.22-15.06]；P <0.05）：我们的研究表明，MGUS 患者患骨质疏松症的风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

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0.00%

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期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.