Exploring the link between celiac disease and obesity: a potential role of gut microbiome.

IF 3.4 Q2 GASTROENTEROLOGY & HEPATOLOGY Intestinal Research Pub Date : 2024-11-08 DOI:10.5217/ir.2024.00049

Sunaina Addanki, Anastasia Mashukova, Arkene Levy

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Abstract

Background/aims: In today's age, celiac disease (CD) is no longer solely characterized by chronic diarrhea in a malnourished child. Obesity is gradually being acknowledged as part of CD's clinical course. Both conditions have been linked to alterations of gut microbiome. Given the difficulty of strict gluten-free diet adherence, there is a need for less restrictive adjunctive therapies. We aimed to investigate the prevalence of obesity in patients diagnosed with CD with the goal of developing new therapeutic approaches.

Methods: Baseline data from the National Institute of Health's All of Us Research Program, was used to evaluate the relationship between CD and obesity. A retrospective cohort study was conducted where groups of individuals with CD and without CD were matched by age range and health surveys. Statistical analysis with odds ratios (OR) with 95% confidence intervals (CI) were reported.

Results: The prevalence of obesity was 32.6% in the CD group compared to 18.4% in the control group (OR, 2.111; 95% CI, 1.914-2.328; P< 0.0001). Women accounted for a greater population of patients with CD and obesity. The largest percentage of patients with CD and obesity were older than 65 years. The highest percentage of individuals in both the experimental and control groups were white, followed by African Americans.

Conclusions: Our data shows a significant association between CD and increased prevalence of obesity. These results warrant further investigation into microbial changes and dietary exposures that affect the pathogenesis of both diseases.

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探索乳糜泻与肥胖之间的联系：肠道微生物组的潜在作用。

背景/目的：在当今时代，乳糜泻（CD）不再仅仅以营养不良儿童的慢性腹泻为特征。肥胖逐渐被认为是乳糜泻临床病程的一部分。这两种疾病都与肠道微生物群的改变有关。由于难以严格遵守无麸质饮食，因此需要限制性较小的辅助疗法。我们旨在调查被诊断为 CD 患者的肥胖患病率，以开发新的治疗方法：方法：利用美国国立卫生研究院 "我们所有人研究计划"（All of Us Research Program）的基线数据来评估 CD 与肥胖之间的关系。我们进行了一项回顾性队列研究，将患有 CD 和未患有 CD 的人群按照年龄范围和健康调查进行配对。结果显示，肥胖症的发病率和肥胖率之间存在着明显的差异：结果：CD组肥胖率为32.6%，而对照组为18.4%（OR，2.111；95% CI，1.914-2.328；P< 0.0001）。在 CD 和肥胖症患者中，女性占更大比例。65 岁以上的 CD 和肥胖症患者所占比例最大。实验组和对照组中白人比例最高，其次是非裔美国人：我们的数据显示 CD 与肥胖症患病率增加之间存在明显关联。这些结果值得进一步研究影响这两种疾病发病机制的微生物变化和饮食暴露。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Intestinal Research GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.40

自引率

10.20%

发文量

审稿时长

38 weeks

期刊介绍： Intestinal Research (Intest Res) is the joint official publication of the Asian Organization for Crohn''s and Colitis (AOCC), Chinese Society of IBD (CSIBD), Japanese Society for IBD (JSIBD), Korean Association for the Study of Intestinal Diseases (KASID), Taiwan Society of IBD (TSIBD) and Colitis Crohn''s Foundation (India) (CCF, india). The aim of the Journal is to provide broad and in-depth analysis of intestinal diseases, especially inflammatory bowel disease, which shows increasing tendency and significance. As a Journal specialized in clinical and translational research in gastroenterology, it encompasses multiple aspects of diseases originated from the small and large intestines. The Journal also seeks to propagate and exchange useful innovations, both in ideas and in practice, within the research community. As a mode of scholarly communication, it encourages scientific investigation through the rigorous peer-review system and constitutes a qualified and continual platform for sharing studies of researchers and practitioners. Specifically, the Journal presents up-to-date coverage of medical researches on the physiology, epidemiology, pathophysiology, clinical presentations, and therapeutic interventions of the intestinal diseases. General topics of interest include inflammatory bowel disease, colon and small intestine cancer or polyp, endoscopy, irritable bowel syndrome and other motility disorders, infectious enterocolitis, intestinal tuberculosis, and so forth. The Journal publishes diverse types of academic materials such as editorials, clinical and basic reviews, original articles, case reports, letters to the editor, brief communications, perspective, statement or commentary, and images that are useful to clinicians and researchers.