Circulating tumor HPV DNA as a specific biomarker for cervical cancer.

IF 2.6 3区医学 Q2 OBSTETRICS & GYNECOLOGY International Journal of Gynecology & Obstetrics Pub Date : 2024-11-08 DOI:10.1002/ijgo.16011

Tao Wu, Rumei Sun, Jianan Sun, Xuanran Tao, Juming Su, Shujun Kong, Tao Chen

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Abstract

Objective: The aim of this study was to determine whether circulating tumor human papillomavirus (HPV) DNA is a potential specific biomarker for cervical cancer (CC).

Methods: This retrospective matched study included 87 patients with cervical intraepithelial neoplasia (CIN), 29 CC patients (FIGO IA1-IVA) and 29 HPV-negative controls at Yuhuangding Hospital of Qingdao University (from July 2022 to September 2023). The digital droplet PCR (ddPCR) was used to detect and quantify ctHPV DNA in the plasma of patients with HPV16, 18, 33, 52, or 58-associated CC.

Results: The ctHPV DNA was exclusively detectable in HPV-positive samples, with no detection in patients across various CIN stages (n = 87) or HPV-negative controls (n = 29). Additionally, ctHPV DNA was identified in nine out of 10 late-stage patients (90%) and six out of 19 early-stage patients (31.6%).

Conclusion: The ctHPV DNA serves as a specific biomarker for the diagnosis CC. Additionally, this discovery addresses the knowledge gap in ctHPV DNA research in the early stages of CC and promotes clinical diagnosis and treatment strategies.

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将循环肿瘤 HPV DNA 作为宫颈癌的特异性生物标记物。

目的：本研究旨在确定循环肿瘤人乳头瘤病毒（HPV）DNA 是否是宫颈癌（CC）的潜在特异性生物标记物：本研究旨在确定循环肿瘤人乳头瘤病毒（HPV）DNA是否是宫颈癌（CC）的潜在特异性生物标志物：这项回顾性配对研究纳入了青岛大学附属玉皇顶医院的87名宫颈上皮内瘤变（CIN）患者、29名CC患者（FIGO IA1-IVA）和29名HPV阴性对照者（2022年7月至2023年9月）。采用数字液滴PCR（ddPCR）技术对HPV16、18、33、52或58型相关CC患者血浆中的ctHPV DNA进行检测和定量：结果：ctHPV DNA只能在HPV阳性样本中检测到，在不同CIN分期的患者（n = 87）或HPV阴性对照组（n = 29）中均未检测到。此外，10 例晚期患者中有 9 例（90%）和 19 例早期患者中有 6 例（31.6%）发现了 ctHPV DNA：结论：ctHPV DNA是诊断CC的特异性生物标志物。结论：ctHPV DNA是诊断CC的特异性生物标志物，这一发现填补了ctHPV DNA研究在CC早期阶段的知识空白，促进了临床诊断和治疗策略的制定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Gynecology & Obstetrics 医学-妇产科学

CiteScore

5.80

自引率

2.60%

发文量

493

审稿时长

3-6 weeks

期刊介绍： The International Journal of Gynecology & Obstetrics publishes articles on all aspects of basic and clinical research in the fields of obstetrics and gynecology and related subjects, with emphasis on matters of worldwide interest.