Valerie Builoff, Cathleen Huang, Keiichiro Kuronuma, Chih-Chun Wei, Hidesato Fujito, Yuka Otaki, Serge D Van Kriekinge, Paul Kavanagh, Mark Lemley, Mark C Hyun, Marcelo Di Carli, Daniel S Berman, Piotr J Slomka
{"title":"Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in <sup>18</sup>F-flurpiridaz PET-MPI.","authors":"Valerie Builoff, Cathleen Huang, Keiichiro Kuronuma, Chih-Chun Wei, Hidesato Fujito, Yuka Otaki, Serge D Van Kriekinge, Paul Kavanagh, Mark Lemley, Mark C Hyun, Marcelo Di Carli, Daniel S Berman, Piotr J Slomka","doi":"10.1016/j.nuclcard.2024.102072","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from <sup>18</sup>F-flurpiridaz PET myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for <sup>18</sup>F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).</p><p><strong>Methods: </strong>In total, 231 patients who underwent invasive coronary angiography and rest/pharmacologic stress <sup>18</sup>F-flurpiridaz PET-MPI from phase III Flurpiridaz trial (NCT01347710) were enrolled. For manual MC, two operators (Reader 1 and Reader 2) shifted each frame's images in three directions. The automatic MC algorithm, initially developed for <sup>82</sup>Rb-chloride PET-MPI, was optimized for <sup>18</sup>F-flurpiridaz. Diagnostic performance was compared using minimal segmental MBF/MFR with and without MC to predict CAD ≥70% stenosis by angiography.</p><p><strong>Results: </strong>Manual MC took 10 minutes per case (both stress and rest) on average, while automatic MC required <17 seconds. The area under the receiver operating characteristic curves (AUCs) for significant CAD using minimal segmental MBF were comparable between automatic and manual MC (AUC=0.877 automatic, AUC=0.888 Reader 1 and AUC=0.892 Reader 2; all p>0.05). AUCs of minimal segmental MBF with manual and automatic MC were significantly higher than without MC (p<0.05 for both). Similar findings were observed with minimal segmental MFR.</p><p><strong>Conclusions: </strong>Automatic MC can be performed rapidly, with diagnostic performance for predicting obstructive CAD comparable to manual MC. This method could be utilized for analysis of MBF/MFR in patients undergoing <sup>18</sup>F-flurpiridaz PET-MPI.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0000,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nuclear Cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.nuclcard.2024.102072","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from 18F-flurpiridaz PET myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for 18F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).
Methods: In total, 231 patients who underwent invasive coronary angiography and rest/pharmacologic stress 18F-flurpiridaz PET-MPI from phase III Flurpiridaz trial (NCT01347710) were enrolled. For manual MC, two operators (Reader 1 and Reader 2) shifted each frame's images in three directions. The automatic MC algorithm, initially developed for 82Rb-chloride PET-MPI, was optimized for 18F-flurpiridaz. Diagnostic performance was compared using minimal segmental MBF/MFR with and without MC to predict CAD ≥70% stenosis by angiography.
Results: Manual MC took 10 minutes per case (both stress and rest) on average, while automatic MC required <17 seconds. The area under the receiver operating characteristic curves (AUCs) for significant CAD using minimal segmental MBF were comparable between automatic and manual MC (AUC=0.877 automatic, AUC=0.888 Reader 1 and AUC=0.892 Reader 2; all p>0.05). AUCs of minimal segmental MBF with manual and automatic MC were significantly higher than without MC (p<0.05 for both). Similar findings were observed with minimal segmental MFR.
Conclusions: Automatic MC can be performed rapidly, with diagnostic performance for predicting obstructive CAD comparable to manual MC. This method could be utilized for analysis of MBF/MFR in patients undergoing 18F-flurpiridaz PET-MPI.
期刊介绍：
Journal of Nuclear Cardiology is the only journal in the world devoted to this dynamic and growing subspecialty. Physicians and technologists value the Journal not only for its peer-reviewed articles, but also for its timely discussions about the current and future role of nuclear cardiology. Original articles address all aspects of nuclear cardiology, including interpretation, diagnosis, imaging equipment, and use of radiopharmaceuticals. As the official publication of the American Society of Nuclear Cardiology, the Journal also brings readers the latest information emerging from the Society''s task forces and publishes guidelines and position papers as they are adopted.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
