Common and contrasting effects of 5-HTergic signaling in pyramidal cells and SOM interneurons of the mouse cortex.

IF 6.6 1区医学 Q1 NEUROSCIENCES Neuropsychopharmacology Pub Date : 2024-11-07 DOI:10.1038/s41386-024-02022-x

Nathalie Schmitz, Sadat Hodzic, Therese Riedemann

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Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a powerful modulator of neuronal activity within the central nervous system and dysfunctions of the serotonergic system have been linked to several neuropsychiatric disorders such as major depressive disorders or schizophrenia. The anterior cingulate cortex (aCC) plays an important role in cognitive capture of stimuli and valence processing and it is densely innervated by serotonergic fibers from the nucleus raphe. In order to understand how pathophysiological 5-HT signalling can lead to neuropsychiatric diseases, it is important to understand the physiological actions of 5-HT on cortical circuits. Therefore, we combined electrophysiological recordings with pharmacology and immunocytochemistry to investigate the effects of 5-HT on Somatostatin-positive interneurons (SOM-INs) and compared these to supragranular pyramidal cells (PCs). This comparison allowed us to identify common and contrasting effects of 5-HT on SOM-INs and PCs of the aCC resulting in a specific modulation of the excitation-to-inhibition balance in PCs but not in SOM-INs.

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5-HTergic 信号在小鼠大脑皮层锥体细胞和 SOM 中间神经元中的共同效应和对比效应。

血清素（5-羟色胺，5-HT）是中枢神经系统内神经元活动的强大调节器，血清素能系统的功能障碍与多种神经精神疾病有关，如重度抑郁症或精神分裂症。前扣带回皮层（anterior cingulate cortex，aCC）在对刺激的认知捕捉和价值处理中发挥着重要作用，它密集地接受来自剑突核的血清素能纤维的神经支配。为了了解病理生理的 5-HT 信号如何导致神经精神疾病，了解 5-HT 对皮层回路的生理作用非常重要。因此，我们将电生理记录与药理学和免疫细胞化学结合起来，研究 5-HT 对体泌素阳性中间神经元（SOM-INs）的影响，并将其与颅上锥体细胞（PCs）进行比较。通过这种比较，我们确定了 5-HT 对 aCC 的 SOM-INs 和 PCs 的共同作用和对比作用，从而对 PCs（而非 SOM-INs）的兴奋-抑制平衡进行了特定调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuropsychopharmacology 医学-精神病学

CiteScore

15.00

自引率

2.60%

发文量

240

审稿时长

2 months

期刊介绍： Neuropsychopharmacology is a reputable international scientific journal that serves as the official publication of the American College of Neuropsychopharmacology (ACNP). The journal's primary focus is on research that enhances our knowledge of the brain and behavior, with a particular emphasis on the molecular, cellular, physiological, and psychological aspects of substances that affect the central nervous system (CNS). It also aims to identify new molecular targets for the development of future drugs. The journal prioritizes original research reports, but it also welcomes mini-reviews and perspectives, which are often solicited by the editorial office. These types of articles provide valuable insights and syntheses of current research trends and future directions in the field of neuroscience and pharmacology.