Efficacy of the Rezūm System for lower urinary tract symptoms in patients with benign prostatic hyperplasia: Long term results from a single centre prospective study.

IF 0.8 Q4 UROLOGY & NEPHROLOGY Urologia Journal Pub Date : 2024-11-08 DOI:10.1177/03915603241297137
Angelo Totaro, Filippo Gavi, Daniele Fettucciari, Francesco Pio Bizzarri, Domenico Sanesi, Luigi Cosenza, Filippo Marino, Antonio Cretì, Pierluigi Russo, Emilio Sacco
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Abstract

Introduction: Benign prostatic hyperplasia (BPH) is a prevalent urological condition leading to lower urinary tract symptoms. Minimal invasive surgical treatment (MISTs) such as Rezūm System are emerging aiming to relieve symptoms. We present results from a single centre prospective study.

Methods: We prospectively followed patients undergoing Rezūm between 2021 and 2023 from a single centre. International Prostate Symptom Score (IPSS), functional outcomes (maximum urinary flow rate (Qmax) and post-void urinary residual (PVR) and International Index of Erectile Function-5 (IIEF-5) were assessed at 3, 6, 12 and 24 months. Anterograde ejaculation was assessed at 12 months follow up. Linear mixed-effects models (LMMs) for repeated measures were applied to assess differences in the IPSS, maximum flow rate (Qmax), PVR, and International Index of Erectile Function-5 (IIEF-5) from baseline (t0) to 3, 6, 12 and 24 months. Results: After adjusting for prostate volume and symptoms severity, significant differences were observed at 3, 6, 12 and 24 months for IPSS (p < 0.001), Qmax (p < 0.001), PVR (p < 0.001) and IPSS-QoL (p < 0.001) from baseline. No statistically significant changes were found in the IIEF-5 scores at 3, 6, 12 and 24 months from baseline. Anterograde ejaculation remained in 98% of patients after treatment.

Conclusions: In conclusion, the study's findings indicate that patients undergoing Rezūm treatment experience sustained improvements in IPSS, Qmax, PVR and IPSS-related quality of life up to 24 months following the intervention. Anterograde ejaculation remained in 98% of patients after treatment.

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Rezūm 系统对良性前列腺增生患者下尿路症状的疗效:单中心前瞻性研究的长期结果。
导言:良性前列腺增生症(BPH)是一种导致下尿路症状的常见泌尿系统疾病。以缓解症状为目的的微创手术治疗(MIST)(如 Rezūm 系统)正在兴起。我们展示了一项单中心前瞻性研究的结果:方法:我们对 2021 年至 2023 年期间在一个中心接受 Rezūm 治疗的患者进行了前瞻性随访。在3、6、12和24个月时评估国际前列腺症状评分(IPSS)、功能结果(最大尿流率(Qmax)和排尿后残余尿(PVR))以及国际勃起功能指数-5(IIEF-5)。随访 12 个月时对逆行射精进行评估。应用线性混合效应模型(LMMs)进行重复测量,以评估 IPSS、最大流速(Qmax)、PVR 和国际勃起功能指数-5(IIEF-5)从基线(t0)到 3、6、12 和 24 个月的差异。结果:调整前列腺体积和症状严重程度后,3、6、12 和 24 个月时的 IPSS 与基线相比有显著差异(p p p < 0.001)。IIEF-5评分在3个月、6个月、12个月和24个月时与基线相比没有统计学意义上的明显变化。98%的患者在治疗后仍能保持逆行射精:总之,研究结果表明,接受 Rezūm 治疗的患者在干预后的 24 个月内,IPSS、Qmax、PVR 和 IPSS 相关生活质量都有持续改善。98%的患者在治疗后仍能保持逆行射精。
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来源期刊
Urologia Journal
Urologia Journal UROLOGY & NEPHROLOGY-
CiteScore
0.60
自引率
12.50%
发文量
66
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