Global cancer statistics of young adults and its changes in the past decade: Incidence and mortality from GLOBOCAN 2022

IF 3.9 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Public Health Pub Date : 2024-11-07 DOI:10.1016/j.puhe.2024.10.033

Jian Li , Xiaohong Kuang

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Abstract

Objectives

This study aimed to assess the disease burden of cancer in young adults globally and the changes between 2012 and 2022.

Study design

A comprehensive analysis of global cancer statistics of young adults based on data provided by GLOBOCAN 2022.

Methods

The incidence and mortality estimates for cancer in young adults in 2012 and 2022 were obtained from the publication by Fidler et al. and GLOBOCAN 2022, respectively. Data were displayed descriptively and compared at the sex, global, regional, national and human development index (HDI) levels. Associations between HDI rank and cancer incidence and mortality were explored by Pearson correlation analysis.

Results

In 2022, the number of new cancer cases and deaths in young adults were estimated to be 1,227,907 and 349,550, respectively, with the age-standardised incidence rate (ASIR) and age-standardised mortality rate (ASMR) of 49.5 and 14.2 per 100,000 population. In young adults, 47.22 % of new cases were breast, thyroid and cervical cancer, while the leading causes of cancer-related death were breast, leukaemia and cervical cancer. Compared to 2012, the number of new cases and the ASIR increased by 25.89 % and 14.32 %, respectively, while the number of deaths and the ASMR decreased by 2.03 % and 10.69 %, respectively. However, cancer burden and its changes varied substantially across geographical regions, HDI levels and cancer types. In general, infection-related cancers were more common in less developed regions, but their incidence decreased significantly, while Westernised lifestyle-related cancers were more common in developed countries and their incidence is increasing.

Conclusions

Cancer contributes substantially to health-related burdens in young adults and the overall incidence has increased dramatically in the past decade. However, the incidence and mortality of cancer in this age group varied considerably by sex, cancer type, region, country and HDI level.

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全球青壮年癌症统计数据及其在过去十年中的变化：2022 年 GLOBOCAN 的发病率和死亡率。

研究目的本研究旨在评估全球青壮年癌症疾病负担以及 2012 年至 2022 年间的变化：研究设计：根据 GLOBOCAN 2022 提供的数据，对全球青壮年癌症统计数据进行综合分析：2012年和2022年青壮年癌症发病率和死亡率估计值分别来自Fidler等人的出版物和GLOBOCAN 2022。数据以描述性方式显示，并在性别、全球、地区、国家和人类发展指数（HDI）层面进行比较。通过皮尔逊相关分析探讨了人类发展指数排名与癌症发病率和死亡率之间的关系：2022 年，青壮年新增癌症病例和死亡人数估计分别为 1,227,907 例和 349,550 例，年龄标准化发病率（ASIR）和年龄标准化死亡率（ASMR）分别为每 10 万人 49.5 例和 14.2 例。在青壮年中，47.22%的新发病例为乳腺癌、甲状腺癌和宫颈癌，而癌症相关死亡的主要原因是乳腺癌、白血病和宫颈癌。与 2012 年相比，新发病例数和 ASIR 分别增加了 25.89 % 和 14.32 %，而死亡人数和 ASMR 分别减少了 2.03 % 和 10.69 %。然而，癌症负担及其变化在不同地理区域、人类发展指数水平和癌症类型之间存在很大差异。一般来说，与感染相关的癌症在欠发达地区更为常见，但其发病率显著下降，而与西方化生活方式相关的癌症在发达国家更为常见，其发病率正在上升：结论：癌症是造成青壮年健康负担的主要原因，在过去十年中，癌症的总发病率急剧上升。然而，这一年龄组的癌症发病率和死亡率因性别、癌症类型、地区、国家和人类发展指数水平的不同而有很大差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Public Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.60

自引率

0.00%

发文量

280

审稿时长

37 days

期刊介绍： Public Health is an international, multidisciplinary peer-reviewed journal. It publishes original papers, reviews and short reports on all aspects of the science, philosophy, and practice of public health.