Management of pediatric thyroid carcinoma.

IF 1.9 4区医学 Q2 OTORHINOLARYNGOLOGY Current Opinion in Otolaryngology & Head and Neck Surgery Pub Date : 2024-12-01 Epub Date: 2024-10-16 DOI:10.1097/MOO.0000000000001012

Amy L Dimachkieh, Priya Mahajan

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Abstract

Purpose of review: The incidence of thyroid carcinoma is increasing among children and adolescents, particularly in female individuals. Children and adolescents require special considerations in management as the molecular genetics of pediatric thyroid tumors are inherently different from their adult counterparts. The increased risk of malignancy, nodal metastases, and pulmonary metastases in pediatric patients warrants pediatric-specific management recommendations and pediatric-specific multidisciplinary teams.

Recent findings: This article highlights the molecular origins of pediatric thyroid carcinoma and the implications of tumor genetics for the course of disease and treatment considerations. We highlight specific surgical considerations to optimize outcomes while minimizing lifelong risks of vocal paralysis and hypoparathyroidism. The landscape of treatment options is rapidly evolving with development of sophisticated molecular approaches to understand the genetic landscape, and this review features updated recommendations and systemic treatment options for the management of pediatric thyroid malignancy.

Summary: Pediatric thyroid carcinoma is a lifelong burden and the treatment tailored to optimize outcomes minimizes long-term risks of treatments, surgery, radiation and targeted systemic therapies. Multidisciplinary teams that treat pediatric thyroid carcinoma should focus surgical experience and use the most updated guidelines and treatments available, particularly considering the landscape of molecular genetics in pediatric thyroid carcinoma.

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小儿甲状腺癌的治疗

审查目的：甲状腺癌在儿童和青少年中的发病率越来越高，尤其是女性。由于小儿甲状腺肿瘤的分子遗传学本质上不同于成人，因此儿童和青少年的治疗需要特别考虑。儿科患者恶性肿瘤、结节转移和肺转移的风险增加，因此需要针对儿科的管理建议和针对儿科的多学科团队：本文重点介绍了小儿甲状腺癌的分子起源以及肿瘤遗传学对病程和治疗注意事项的影响。我们强调了具体的手术注意事项，以优化治疗效果，同时最大限度地降低声带麻痹和甲状旁腺功能减退的终身风险。随着了解遗传情况的复杂分子方法的发展，治疗方案也在迅速演变，本综述介绍了治疗小儿甲状腺恶性肿瘤的最新建议和系统治疗方案。摘要：小儿甲状腺癌是一种终身负担，为优化治疗效果而量身定制的治疗方案可最大限度地降低治疗、手术、放射和系统靶向治疗的长期风险。治疗小儿甲状腺癌的多学科团队应集中手术经验，采用现有的最新指南和治疗方法，特别是考虑到小儿甲状腺癌的分子遗传学情况。

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来源期刊

Current Opinion in Otolaryngology & Head and Neck Surgery OTORHINOLARYNGOLOGY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Otolaryngology & Head and Neck Surgery is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With eleven disciplines published across the year – including maxillofacial surgery, head and neck oncology and speech therapy and rehabilitation – every issue also contains annotated references detailing the merits of the most important papers.

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