Fabrication of a natural nanocomposite from Syzygium cumini and squid bone waste decorated with Cu-Nps for simultaneous use in the triple method of photodynamic/photothermal/chemotherapy.

Biomedical materials (Bristol, England) Pub Date : 2024-11-18 DOI:10.1088/1748-605X/ad909e

Mohsen Mehrabi, Ali Shaygan Shirazi, Fatemeh Gharibzadeh, Hossein Shirkani, Amirhossein Ghaedi, Arezoo Khoradmehr

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Abstract

This work reports a new nano platform made from natural materials for phototherapy (PT) applications. For this purpose, calcium carbonate nanoparticles (NPs) derived from Persian Gulf squid bones as a drug carrier, Syzygium cumini (dye extracted from the fruit of the Persian Gulf trees) as a photosensitizer, and Doxorubicin as a chemotherapy (CHT) drug have been used. In addition, copper NPs were added to the above nanocomposition to increase the efficiency of photothermal (PTT) treatment. For PT, samples were irradiated by an 808 nm laser (1 W cm^-2). The results show that nanocomposites play an influential role in the reactive oxygen species process, and an increase of 21 degrees in temperature during 15 min of laser radiation is effective in photodynamic (PDT)/PTT therapy. The drug loading capacity of the nanocomposite was calculated as 49%. This new nanocomposite for simultaneous PDT/PTT/CHT holds great promise for future cancer treatment due to its excellent potential in treatment and reduced systemic toxicity.

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从茜草和乌贼骨废料中制备出一种天然纳米复合材料，用 Cu-Nps 进行装饰，同时用于光动力/光热/化学治疗三重方法。

这项工作报告了一种由天然材料制成的新型纳米平台。为此，研究人员使用了从波斯湾乌贼骨中提取的碳酸钙纳米粒子作为药物载体，茜草（从波斯湾树木果实中提取的染料）作为光敏剂，多柔比星作为化疗药物。此外，上述成分中还添加了纳米铜粒子，以提高光热治疗的效率。在光疗过程中，用波长为 808 纳米（1 W）的激光照射样品。结果表明，纳米复合材料在活性氧过程中发挥了影响作用，在激光照射 15 分钟内温度升高 21 度对光动力/光热疗法有效。经计算，该纳米复合材料的载药量为 49%。这种同时用于光动力/光热/化疗的新型纳米复合材料因其出色的治疗潜力和较低的全身毒性，在未来的癌症治疗中大有可为。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedical materials (Bristol, England)

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