Effect of Baseline Values of Renal Prognosis-related Factors on Their Changes after Initiating Tofogliflozin Treatment: A Retrospective Study in Japanese Patients with Type 2 Diabetes and Renal Impairment.

IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL JMA journal Pub Date : 2024-10-15 Epub Date: 2024-09-06 DOI:10.31662/jmaj.2024-0128
Suzuko Matsumoto, Hiroyuki Ito, Hideyuki Inoue, Chiaki I, Shun Miura, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane
{"title":"Effect of Baseline Values of Renal Prognosis-related Factors on Their Changes after Initiating Tofogliflozin Treatment: A Retrospective Study in Japanese Patients with Type 2 Diabetes and Renal Impairment.","authors":"Suzuko Matsumoto, Hiroyuki Ito, Hideyuki Inoue, Chiaki I, Shun Miura, Shinichi Antoku, Tomoko Yamasaki, Toshiko Mori, Michiko Togane","doi":"10.31662/jmaj.2024-0128","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study investigated the relationships between changes in renal prognosis-related factors after initiating tofogliflozin and the corresponding baseline values in clinical practice in Japanese patients with type 2 diabetes.</p><p><strong>Methods: </strong>We investigated the relationships between changes in hematocrit, hemoglobin, systolic blood pressure (sBP), urinary protein excretion (uPE), serum uric acid (sUA), and estimated glomerular filtration rate (eGFR) 12 months after initiating tofogliflozin (20 mg) and their corresponding baseline values in 130 patients with type 2 diabetes. The subjects were divided into two groups: normal (≥60 mL/min/1.73 m<sup>2</sup>, n = 87) and low (<60 mL/min/1.73 m<sup>2</sup>, n = 43) eGFR.</p><p><strong>Results: </strong>Although the change in eGFR was negatively correlated with the baseline value in the normal-eGFR group, no significant correlation was found between the change in eGFR and baseline value in the low-eGFR group. Although changes in hematocrit (r = -0.39, P = 0.01) and hemoglobin (r = -0.36, P = 0.02) levels were significantly negatively correlated with corresponding baseline values in the low-eGFR group, no significant correlations were observed in the normal-eGFR group. Changes in sBP, uPE, and sUA were significantly negatively correlated with the corresponding baseline values in both the normal- and low-eGFR groups. None of the correlation coefficients between the normal- and low-eGFR groups showed a significant difference.</p><p><strong>Conclusions: </strong>Favorable changes in renal prognosis-related factors after tofogliflozin therapy may contribute to renoprotection in patients with type 2 diabetes and poor corresponding baseline values, despite the presence of renal impairment.</p>","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"7 4","pages":"571-579"},"PeriodicalIF":1.5000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543293/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JMA journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31662/jmaj.2024-0128","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: This study investigated the relationships between changes in renal prognosis-related factors after initiating tofogliflozin and the corresponding baseline values in clinical practice in Japanese patients with type 2 diabetes.

Methods: We investigated the relationships between changes in hematocrit, hemoglobin, systolic blood pressure (sBP), urinary protein excretion (uPE), serum uric acid (sUA), and estimated glomerular filtration rate (eGFR) 12 months after initiating tofogliflozin (20 mg) and their corresponding baseline values in 130 patients with type 2 diabetes. The subjects were divided into two groups: normal (≥60 mL/min/1.73 m2, n = 87) and low (<60 mL/min/1.73 m2, n = 43) eGFR.

Results: Although the change in eGFR was negatively correlated with the baseline value in the normal-eGFR group, no significant correlation was found between the change in eGFR and baseline value in the low-eGFR group. Although changes in hematocrit (r = -0.39, P = 0.01) and hemoglobin (r = -0.36, P = 0.02) levels were significantly negatively correlated with corresponding baseline values in the low-eGFR group, no significant correlations were observed in the normal-eGFR group. Changes in sBP, uPE, and sUA were significantly negatively correlated with the corresponding baseline values in both the normal- and low-eGFR groups. None of the correlation coefficients between the normal- and low-eGFR groups showed a significant difference.

Conclusions: Favorable changes in renal prognosis-related factors after tofogliflozin therapy may contribute to renoprotection in patients with type 2 diabetes and poor corresponding baseline values, despite the presence of renal impairment.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肾脏预后相关因素基线值对开始托非格列净治疗后其变化的影响:一项针对日本 2 型糖尿病肾功能损害患者的回顾性研究
内容简介本研究调查了日本 2 型糖尿病患者开始服用托非格列净后肾脏预后相关因素的变化与临床实践中相应基线值之间的关系:我们研究了130名2型糖尿病患者服用托非格列净(20毫克)12个月后血细胞比容、血红蛋白、收缩压(sBP)、尿蛋白排泄量(uPE)、血清尿酸(sUA)和估计肾小球滤过率(eGFR)的变化与其相应基线值之间的关系。受试者分为两组:正常(≥60 mL/min/1.73 m2,n = 87)和低(2,n = 43)eGFR:结果:虽然在正常 eGFR 组中,eGFR 的变化与基线值呈负相关,但在低 eGFR 组中,eGFR 的变化与基线值之间没有发现明显的相关性。虽然在低 eGFR 组中,血细胞比容(r = -0.39,P = 0.01)和血红蛋白(r = -0.36,P = 0.02)水平的变化与相应的基线值呈显著负相关,但在正常 eGFR 组中未观察到明显的相关性。在正常组和低 eGFR 组中,sBP、uPE 和 sUA 的变化均与相应的基线值呈显著负相关。正常组和低 EGFR 组之间的相关系数均无明显差异:结论:尽管2型糖尿病患者存在肾功能损害,但在接受托非格列净治疗后,肾脏预后相关因素的有利变化可能有助于肾脏保护。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
High Prevalence of Nephrocalcinosis in Hypophosphatasia Patients with the ALPL c.1559del Gene Variant. Hospital-based Introduction of Untested High-risk Foods for Down Syndrome Infant with Severe Food Protein-induced Enterocolitis Syndrome: A Case Report. How Healthy Lifestyle Habits Have Interacted with SARS-CoV-2 Infection and the Effectiveness of COVID-19 Vaccinations: A Comment. How Will Work Hour Restrictions Transform the Working Conditions of Resident Physicians? Hypotensive Dumping Syndrome in Hypertrophic Obstructive Cardiomyopathy.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1