Cost-effective synthesis and application of Cu²⁺-doped melamine formaldehyde resin for enhanced tetracycline enrichment in environmental water

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS Journal of Chromatography A Pub Date : 2024-11-02 DOI:10.1016/j.chroma.2024.465499

Lin Gu , Junyu Zhang , Shuhai Ding , Longlong Wang , Wei Xia , Peng Wang , Wenlei Zhai , Cong Kong , Xiaosheng Shen , Chengqi Fan , Guangxin Yang

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Abstract

Tetracycline antibiotics (TCs) are typically present at low residue levels in environmental water, necessitating enrichment prior to analysis. In this study, a Cu²⁺-doped melamine formaldehyde resin (Cu-MFR) was synthesized to enhance the adsorption efficiency for TCs, leveraging the formation of stable Cu²⁺-TC complexes on the sorbent surface. Then it was used as an adsorbent in solid-phase extraction (SPE) for the enrichment of four TCs from water samples. The optimized parameters for Cu-MFR in the analysis of TCs in environmental water enabled linear detection ranges from 0.20 to 50 ng/mL, with relative recoveries ranging from 79.5 % to 97.6 % and relative standard deviations ≤ 10.0 %, using high-performance liquid chromatography-tandem high-resolution mass spectrometry (HPLC-HRMS). The limits of detection for the four TCs were determined to be between 0.11 and 0.16 ng/mL, indicating its potential for practical application in real sample analysis.

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掺杂 Cu²⁺ 的三聚氰胺甲醛树脂的成本效益合成与应用，用于提高环境水体中四环素的富集度。

四环素类抗生素（TC）在环境水体中的残留量通常很低，因此需要在分析前进行富集。本研究合成了一种掺杂 Cu2+ 的三聚氰胺甲醛树脂（Cu-MFR），通过在吸附剂表面形成稳定的 Cu2+-TC 复合物来提高 TCs 的吸附效率。然后将其作为固相萃取（SPE）中的吸附剂，用于富集水样中的四种三氯甲烷。利用高效液相色谱-串联高分辨质谱法（HPLC-HRMS）分析环境水样中的 TCs，Cu-MFR 的优化参数可实现 0.20 至 50 ng/mL 的线性检测范围，相对回收率为 79.5 % 至 97.6 %，相对标准偏差小于 10.0 %。四种三氯乙酸的检测限被确定为 0.11 至 0.16 纳克/毫升，这表明该方法在实际样品分析中具有实际应用潜力。

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来源期刊

Journal of Chromatography A 化学-分析化学

CiteScore

7.90

自引率

14.60%

发文量

742

审稿时长

45 days

期刊介绍： The Journal of Chromatography A provides a forum for the publication of original research and critical reviews on all aspects of fundamental and applied separation science. The scope of the journal includes chromatography and related techniques, electromigration techniques (e.g. electrophoresis, electrochromatography), hyphenated and other multi-dimensional techniques, sample preparation, and detection methods such as mass spectrometry. Contributions consist mainly of research papers dealing with the theory of separation methods, instrumental developments and analytical and preparative applications of general interest.