The potential therapeutic strategy in combating neurodegenerative diseases: Focusing on natural products

IF 12 1区医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2024-11-09 DOI:10.1016/j.pharmthera.2024.108751

Li Gao , Xi-Na Yang , Yi-Xiao Dong , Yi-Jia Han , Xin-Yue Zhang , Xin-Le Zhou , Ying Liu , Fang Liu , Jian-Song Fang , Jian-Long Ji , Zheng-Run Gao , Xue-Mei Qin

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Abstract

Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington disease (HD), and Multiple sclerosis (MS), pose a significant global health challenge due to their intricate pathology and limited therapeutic interventions. Natural products represent invaluable reservoirs for combating these neurodegenerative diseases by targeting key pathological hallmarks such as protein aggregation, synaptic dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, inflammation, and neuronal cell death. This review provides an in-depth analysis of the mechanisms and therapeutic targets of natural products for their neuroprotective effects. Furthermore, it elucidates the current progress of clinical trials investigating the potential of natural products in delaying neurodegeneration. The objective of this review is to enhance the comprehension of natural products in the prevention and treatment of neurodegenerative diseases, offering new insights and potential avenues for future pharmaceutical research.

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阿尔茨海默病 (AD)、帕金森病 (PD)、肌萎缩侧索硬化症 (ALS)、亨廷顿病 (HD) 和多发性硬化症 (MS) 等神经退行性疾病病理复杂，治疗干预手段有限，对全球健康构成了巨大挑战。天然产品针对蛋白质聚集、突触功能障碍、异常蛋白稳态、细胞骨架异常、能量稳态改变、炎症和神经细胞死亡等关键病理特征，是抗击这些神经退行性疾病的宝贵宝库。本综述深入分析了天然产品的神经保护作用机制和治疗靶点。此外，它还阐明了目前研究天然产品在延缓神经退行性变方面潜力的临床试验的进展情况。本综述旨在加深人们对天然产品在预防和治疗神经退行性疾病方面的理解，为未来的药物研究提供新的见解和潜在的途径。

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来源期刊

Pharmacology & Therapeutics 医学-药学

CiteScore

23.00

自引率

0.70%

发文量

222

审稿时长

90 days

期刊介绍： Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.