A non-intrusive reduced-order model for finite element analysis of implant positioning in total hip replacements.

IF 3 3区 医学 Q2 BIOPHYSICS Biomechanics and Modeling in Mechanobiology Pub Date : 2024-11-13 DOI:10.1007/s10237-024-01903-w
Marlis Reiber, Fynn Bensel, Zhibao Zheng, Udo Nackenhorst
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Abstract

Sophisticated high-fidelity simulations can predict bone mass density (BMD) changes around a hip implant after implantation. However, these models currently have high computational demands, rendering them impractical for clinical settings. Model order reduction techniques offer a remedy by enabling fast evaluations. In this work, a non-intrusive reduced-order model, combining proper orthogonal decomposition with radial basis function interpolation (POD-RBF), is established to predict BMD distributions for varying implant positions. A parameterised finite element mesh is morphed using Laplace's equation, which eliminates tedious remeshing and projection of the BMD results on a common mesh in the offline stage. In the online stage, the surrogate model can predict BMD distributions for new implant positions and the results are visualised on the parameterised reference mesh. The computational time for evaluating the final BMD distribution around a new implant position is reduced from minutes to milliseconds by the surrogate model compared to the high-fidelity model. The snapshot data, the surrogate model parameters and the accuracy of the surrogate model are analysed. The presented non-intrusive surrogate model paves the way for on-the-fly evaluations in clinical practice, offering a promising tool for planning and monitoring of total hip replacements.

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用于全髋关节置换术植入物定位有限元分析的非侵入式减阶模型。
先进的高保真模拟可以预测髋关节植入物植入后周围骨质密度(BMD)的变化。然而,这些模型目前对计算要求很高,因此在临床环境中并不实用。模型阶次缩减技术通过实现快速评估提供了一种补救措施。在这项研究中,我们建立了一个非侵入式降阶模型,该模型结合了适当的正交分解和径向基函数插值(POD-RBF),用于预测不同植入位置的 BMD 分布。使用拉普拉斯方程对参数化的有限元网格进行变形,从而避免了离线阶段在普通网格上对 BMD 结果进行繁琐的重网格化和投影。在在线阶段,代用模型可以预测新植入位置的 BMD 分布,并在参数化参考网格上显示结果。与高保真模型相比,代用模型评估新植入位置周围最终 BMD 分布的计算时间从几分钟缩短到几毫秒。对快照数据、代用模型参数和代用模型的准确性进行了分析。所介绍的非侵入式代用模型为临床实践中的即时评估铺平了道路,为全髋关节置换术的规划和监测提供了一种前景广阔的工具。
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来源期刊
Biomechanics and Modeling in Mechanobiology
Biomechanics and Modeling in Mechanobiology 工程技术-工程:生物医学
CiteScore
7.10
自引率
8.60%
发文量
119
审稿时长
6 months
期刊介绍: Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.
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