Maurice Hädrich, Clarissa Schulze, Josef Hoff, Bastian Blombach
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引用次数: 0
Abstract
The fast growth accompanied with high substrate consumption rates and a versatile metabolism paved the way to exploit Vibrio natriegens as unconventional host for biotechnological applications. Meanwhile, a wealth of knowledge on the physiology, the metabolism, and the regulation in this halophilic marine bacterium has been gathered. Sophisticated genetic engineering tools and metabolic models are available and have been applied to engineer production strains and first chassis variants of V. natriegens. In this review, we update the current knowledge on the physiology and the progress in the development of synthetic biology tools and provide an overview of recent advances in metabolic engineering of this promising host. We further discuss future challenges to enhance the application range of V. natriegens.
纳氏弧菌生长速度快、底物消耗率高、新陈代谢方式多样，这为将其作为非传统宿主用于生物技术应用铺平了道路。与此同时，有关这种嗜卤海洋细菌的生理学、新陈代谢和调控方面的知识已经非常丰富。目前已有先进的基因工程工具和代谢模型，并已应用于 V. natriegens 的生产菌株和第一个底盘变体的工程设计。在这篇综述中，我们更新了有关生理学的现有知识以及合成生物学工具的开发进展，并概述了这一前景广阔的宿主在代谢工程方面的最新进展。我们还进一步讨论了未来提高 V. natriegens 应用范围的挑战。
期刊介绍：
Advances in Biochemical Engineering/Biotechnology reviews actual trends in modern biotechnology. Its aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required for chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. They give the state-of-the-art of a topic in a comprehensive way thus being a valuable source for the next 3 - 5 years. It also discusses new discoveries and applications.
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