A glucose responsive multifunctional hydrogel with antibacterial properties and real-time monitoring for diabetic wound treatment.

IF 5.8 3区医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Biomaterials Science Pub Date : 2024-11-14 DOI:10.1039/d4bm01097c

Zhifei Yang, Jiaxu Zhang, Chen Wang, Fangzheng Yu, Wen Yu, Zheng Zhao

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Abstract

The healing of complex diabetic wounds with a hyperglycemic microenvironment and bacterial infection is considered an important clinical issue. In this study, glucose oxidase (GOx) and gold nanoclusters (AuNCs) were encapsulated in quaternary carboxymethyl chitosan (QCMCS)/sodium alginate oxide (OSA) hydrogels and were immersed in tannic acid (TA) solution to achieve antioxidant, antibacterial, pro-angiogenesis, pro-collagen deposition and real-time monitoring functions. In vitro studies showed that TA-QCMCS/OSA@GOx@AuNC hydrogels had inhibition rates of 98.99% and 99.99% against S. aureus and E. coli, respectively, and the survival rate of mouse fibroblasts (L929) was over 95%. In vivo studies showed that TA-QCMCS/OSA@GOx@AuNC hydrogels were 97.28% effective in healing diabetic wounds. In addition, image signals from TA-QCMCS/OSA@GOx@AuNC hydrogels can be collected in real time to accurately obtain glucose concentration values of diabetic wounds and reflect the healing status of diabetic wounds in a timely manner. The results showed that TA-QCMCS/OSA@GOx@AuNC hydrogels provide a novel idea for real-time monitoring of diabetic wound treatment.

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一种具有抗菌特性和实时监控功能的葡萄糖反应多功能水凝胶，用于糖尿病伤口治疗。

具有高血糖微环境和细菌感染的复杂糖尿病伤口的愈合被认为是一个重要的临床问题。本研究将葡萄糖氧化酶（GOx）和金纳米团簇（AuNCs）包裹在季羧甲基壳聚糖（QCMCS）/氧化海藻酸钠（OSA）水凝胶中，并浸泡在单宁酸（TA）溶液中，以实现抗氧化、抗菌、促血管生成、促胶原沉积和实时监测功能。体外研究表明，TA-QCMCS/OSA@GOx@AuNC水凝胶对金黄色葡萄球菌和大肠杆菌的抑制率分别为98.99%和99.99%，对小鼠成纤维细胞（L929）的存活率超过95%。体内研究表明，TA-QCMCS/OSA@GOx@AuNC 水凝胶对糖尿病伤口愈合的有效率为 97.28%。此外，TA-QCMCS/OSA@GOx@AuNC 水凝胶的图像信号可实时采集，准确获取糖尿病伤口的葡萄糖浓度值，及时反映糖尿病伤口的愈合状况。结果表明，TA-QCMCS/OSA@GOx@AuNC 水凝胶为糖尿病伤口治疗的实时监测提供了一种新思路。

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来源期刊

Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

11.50

自引率

4.50%

发文量

556

期刊介绍： Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.