Static and Dynamic Functional Network Connectivity in Parkinson's Disease Patients With Postural Instability and Gait Disorder

IF 4.8 1区医学 Q1 NEUROSCIENCES CNS Neuroscience & Therapeutics Pub Date : 2024-11-10 DOI:10.1111/cns.70115

Bo Shen, Qun Yao, Yixuan Zhang, Yinyin Jiang, Yaxi Wang, Xu Jiang, Yang Zhao, Haiying Zhang, Shuangshuang Dong, Dongfeng Li, Yaning Chen, Yang Pan, Jun Yan, Feng Han, Shengrong Li, Qi Zhu, Daoqiang Zhang, Li Zhang, Yun-cheng Wu

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Abstract

Aims

The exact cause of the parkinsonism gait remains uncertain. We first focus on understanding the underlying neurological reasons for these symptoms through the examination of both static functional network connectivity (SFNC) and dynamic functional network connectivity (DFNC).

Methods

We recruited 64 postural instability and gait disorder-dominated Parkinson's disease (PIGD-PD) patients, 31 non-PIGD-PD (nPIGD-PD) patients, and 54 healthy controls (HC) from Nanjing Brain Hospital. The GIFT software identified five distinct independent components: the basal ganglia (BG), cerebellum (CB), sensory networks (SMN), default mode network (DMN), and central executive network (CEN). We conducted a comparison between the SFNC and DFNC of the five networks and analyzed their correlations with postural instability and gait disorder (PIGD) symptoms.

Results

Compared with nPIGD-PD patients, the PIGD-PD patients demonstrated reduced connectivity between CEN and DMN while spending less mean dwell time (MDT) in state 4. This is characterized by strong connections. Compared with HC, PIGD-PD patients exhibited enhanced connectivity in the SFNC between CB and CEN, as well as the network between CB and DMN. Patients with PIGD-PD spent more MDT in state 1, which is characterized by few connections, and less MDT in state 4. In state 3, there was an increase in the functional connectivity between the CB and DMN in patients with PIGD-PD. The nPIGD patients showed increased SFNC connectivity between CB and DMN compared to HC. These patients spent more MDT in state 1 and less in state 4. The MDT and fractional windows of state 2 showed a positive link with PIGD scores.

Conclusion

Patients with PIGD-PD exhibit a higher likelihood of experiencing reduced brain connectivity and impaired information processing. The enhanced connection between the cerebellum and DMN networks is considered a type of dynamic compensation.

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帕金森病患者姿势不稳和步态障碍的静态和动态功能网络连接性

目的：帕金森病步态的确切原因仍不确定。我们首先通过检查静态功能网络连通性（SFNC）和动态功能网络连通性（DFNC）来了解这些症状的潜在神经学原因：我们从南京脑科医院招募了64名姿势不稳和步态障碍为主的帕金森病（PIGD-PD）患者、31名非PIGD-PD（nPIGD-PD）患者和54名健康对照（HC）。GIFT软件识别出了五个不同的独立成分：基底节（BG）、小脑（CB）、感觉网络（SMN）、默认模式网络（DMN）和中央执行网络（CEN）。我们对这五个网络的 SFNC 和 DFNC 进行了比较，并分析了它们与姿势不稳和步态障碍（PIGD）症状的相关性：结果：与非PIGD-PD患者相比，PIGD-PD患者的CEN和DMN之间的连接性降低，同时在状态4中花费的平均停留时间（MDT）减少。这就是强连接的特点。与 HC 相比，PIGD-PD 患者在 CB 和 CEN 之间的 SFNC 以及 CB 和 DMN 之间的网络中表现出更强的连接性。PIGD-PD患者在连接较少的状态1中花费的MDT较多，而在状态4中花费的MDT较少。在状态 3 中，PIGD-PD 患者的 CB 和 DMN 之间的功能连接增加。与 HC 相比，nPIGD 患者的 CB 和 DMN 之间的 SFNC 连接性增加。这些患者在状态 1 中花费的 MDT 更多，而在状态 4 中花费的 MDT 更少。状态 2 的 MDT 和分数窗口与 PIGD 评分呈正相关：结论：PIGD-PD 患者更有可能出现大脑连接性降低和信息处理能力受损的情况。小脑与 DMN 网络之间的连接增强被认为是一种动态补偿。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CNS Neuroscience & Therapeutics 医学-神经科学

CiteScore

7.30

自引率

12.70%

发文量

240

审稿时长

2 months

期刊介绍： CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews and reports of novel findings of therapeutic relevance to the central nervous system, as well as papers related to clinical pharmacology, drug development and novel methodologies for drug evaluation. The journal focuses on neurological and psychiatric diseases such as stroke, Parkinson’s disease, Alzheimer’s disease, depression, schizophrenia, epilepsy, and drug abuse.