Programmable Nanomodulators for Precision Therapy, Engineering Tumor Metabolism to Enhance Therapeutic Efficacy.

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL Advanced Healthcare Materials Pub Date : 2024-11-12 DOI:10.1002/adhm.202403019
Siwei Liu, Zhijun Liu, Huajiang Lei, Yang-Bao Miao, Jiao Chen
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Abstract

Tumor metabolism is crucial in the continuous advancement and complex growth of cancer. The emerging field of nanotechnology has made significant strides in enhancing the understanding of the complex metabolic intricacies inherent to tumors, offering potential avenues for their strategic manipulation to achieve therapeutic goals. This comprehensive review delves into the interplay between tumor metabolism and various facets of cancer, encompassing its origins, progression, and the formidable challenges posed by metastasis. Simultaneously, it underscores the classification of programmable nanomodulators and their transformative impact on enhancing cancer treatment, particularly when integrated with modalities such as chemotherapy, radiotherapy, and immunotherapy. This review also encapsulates the mechanisms by which nanomodulators modulate tumor metabolism, including the delivery of metabolic inhibitors, regulation of oxidative stress, pH value modulation, nanoenzyme catalysis, nutrient deprivation, and RNA interference technology, among others. Additionally, the review delves into the prospects and challenges of nanomodulators in clinical applications. Finally, the innovative concept of using nanomodulators to reprogram metabolic pathways is introduced, aiming to transform cancer cells back into normal cells. This review underscores the profound impact that tailored nanomodulators can have on tumor metabolic, charting a path toward pioneering precision therapies for cancer.

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用于精准治疗的可编程纳米调节剂,通过肿瘤代谢工程提高疗效。
肿瘤代谢对癌症的持续发展和复杂生长至关重要。新兴的纳米技术领域在增进人们对肿瘤内在复杂新陈代谢的了解方面取得了长足的进步,为战略性地操纵肿瘤以实现治疗目标提供了潜在的途径。这篇全面的综述深入探讨了肿瘤代谢与癌症各个方面的相互作用,包括癌症的起源、进展以及转移所带来的严峻挑战。同时,它还强调了可编程纳米调节剂的分类及其对加强癌症治疗的变革性影响,尤其是在与化疗、放疗和免疫疗法等方式相结合时。本综述还概括了纳米调节剂调节肿瘤代谢的机制,包括输送代谢抑制剂、调节氧化应激、pH 值调节、纳米酶催化、营养剥夺和 RNA 干扰技术等。此外,该综述还深入探讨了纳米调节剂在临床应用中的前景和挑战。最后,介绍了使用纳米调节剂重编程代谢途径的创新概念,旨在将癌细胞变回正常细胞。这篇综述强调了量身定制的纳米调节剂对肿瘤代谢的深远影响,为开创癌症精准疗法指明了道路。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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